Does milk increase mucus production?

Medical Hypotheses
Jim Bartley, Susan Read McGlashan

Abstract

Excessive milk consumption has a long association with increased respiratory tract mucus production and asthma. Such an association cannot be explained using a conventional allergic paradigm and there is limited medical evidence showing causality. In the human colon, beta-casomorphin-7 (beta-CM-7), an exorphin derived from the breakdown of A1 milk, stimulates mucus production from gut MUC5AC glands. In the presence of inflammation similar mucus overproduction from respiratory tract MUC5AC glands characterises many respiratory tract diseases. beta-CM-7 from the blood stream could stimulate the production and secretion of mucus production from these respiratory glands. Such a hypothesis could be tested in vitro using quantitative RT-PCR to show that the addition of beta-CM-7 into an incubation medium of respiratory goblet cells elicits an increase in MUC5AC mRNA and by identifying beta-CM-7 in the blood of asthmatic patients. This association may not necessarily be simply cause and effect as the person has to be consuming A1 milk, beta-CM-7 must pass into the systemic circulation and the tissues have to be actively inflamed. These prerequisites could explain why only a subgroup of the population, who have increased respiratory tr...Continue Reading

References

Jan 1, 1991·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·F HaasK Axen
Jul 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M T Nguyen
Feb 4, 1998·The Journal of Allergy and Clinical Immunology·R K WoodsE H Walters
Sep 12, 2000·Current Gastroenterology Reports·D Hollander
Apr 8, 2004·The Journal of the Royal Society for the Promotion of Health·Noor Aini YusoffJane B Morgan
Jul 12, 2007·American Journal of Rhinology·Guo Qiang Ding, Chun Quan Zheng

❮ Previous
Next ❯

Citations

Feb 3, 2016·Current Problems in Pediatric and Adolescent Health Care·Sanghamitra M Misra
Sep 5, 2018·The Laryngoscope·Adam FroshJoanna Stephens
Sep 8, 2018·Archives of Disease in Childhood·Ian M Balfour-Lynn
Feb 9, 2020·Critical Reviews in Food Science and Nutrition·Andrea SummerMassimo Malacarne
Aug 2, 2019·Nutrición hospitalaria·Aránzazu Aparicio VizueteAna María López-Sobaler
Jun 12, 2020·Journal of the International Society of Sports Nutrition·Jill A ParnellKelly Anne Erdman
Aug 18, 2020·Food Chemistry·Muthu ThiruvengadamUmadevi Subramanian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Journal of the American College of Nutrition
Brunello WüthrichRobert Sieber
Archives of Pediatrics & Adolescent Medicine
Christina Lee, Allen J Dozor
American Journal of Physiology. Gastrointestinal and Liver Physiology
Sandra ZoghbiPascale Plaisancié
Respirology : Official Journal of the Asian Pacific Society of Respirology
Daisuke InoueMutsuo Yamaya
© 2022 Meta ULC. All rights reserved