Does MMR status in endometrial cancer influence response to adjuvant therapy?

Gynecologic Oncology
Soyoun Rachel KimJanice S Kwon

Abstract

Mismatch repair (MMR) deficiency occurs in 20-40% of endometrial cancers but its therapeutic implication remains uncertain. Our objective was to compare clinical outcomes after adjuvant therapy between MMR deficient and proficient endometrial cancers from a population-based study. This was a retrospective population-based cohort study of all endometrial cancers from the Vancouver Coastal Health authority region from 2011 to 2016, for which adjuvant therapy (radiotherapy and/or chemotherapy) was administered. Primary outcome measure was recurrence rates, expressed per 100 person-years (p100 py). Progression free survival (PFS) and overall survival (OS) rates were compared using Kaplan-Meier method and log-rank tests, and covariates were evaluated using Cox proportional hazards regression. There were 535 patients who received adjuvant therapy (radiotherapy and/or chemotherapy), including 162 (30.3%) and 373 (69.7%) with MMR-deficient and proficient tumors, respectively. Demographic variables were similar except MMR-deficient patients were younger (62.0 vs. 64.8, p = 0.01). Patients with MMR-deficient tumors were more likely to have endometrioid histotype (85.8% vs. 61.4%), more likely to have Stage I disease (62.3% vs 54.7%), and...Continue Reading

Citations

Aug 21, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jennifer McEachronYi-Chun Lee
Aug 2, 2019·Current Oncology Reports·Bastiaan G WortmanCarien L Creutzberg
Feb 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Annukka PasanenRalf Bützow
May 2, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Soyoun Rachel KimJanice S Kwon
Feb 29, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Kelechi NjokuEmma J Crosbie

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