Does monozygotic twinning occur in mice?

Genetical Research
A McLarenE Signer

Abstract

Published reports suggest that the incidence of monozygotic twinning in women is increased after hormonally induced ovulation. Since some statistical evidence exists to indicate that monozygotic twinning may also occur in mice, we attempted to devise a mouse system in which the incidence of such twinning could be compared after spontaneous versus hormonally induced ovulation, in order to analyse the developmental basis of such an effect. We used phenotypic identity in litters segregating for ten genetic loci (not all independent) to indicate possible twin pairs. DNA finger-printing using three human minisatellite probes was then performed blind on these pairs and on sibling controls. From a total of over 2000 mice born, 40 apparently identical pairs were identified, on which DNA finger-printing was successfully carried out on 35 pairs. All proved to be derived from different zygotes. We conclude that monozygotic twin pairs are either extremely rare in the stock of mice that we studied, or have such reduced viability that their chance of surviving to weaning is low.

References

Jul 25, 1989·Nucleic Acids Research·R E CarterD T Parkin
Mar 1, 1987·Jinrui idengaku zasshi. The Japanese journal of human genetics·K MotomuraA J Jeffreys
Jul 4, 1985·Nature·A J JeffreysS L Thein
Apr 1, 1986·Journal of in Vitro Fertilization and Embryo Transfer : IVF·R G EdwardsD E Walters
Mar 7, 1985·Nature·A J JeffreysS L Thein
Feb 1, 1986·Journal of in Vitro Fertilization and Embryo Transfer : IVF·L E Mobraaten
Nov 1, 1965·Paraplegia·A G Hardy, D W Warrell
Jul 23, 1960·Nature·A J BATEMAN
Mar 1, 1965·Journal of Medical Genetics·M E WALLACE, D A WILLIAMS
Dec 25, 1936·Science·W E CastleG D Snell
Dec 28, 1934·Science·C V Green
Feb 1, 1949·The Journal of Experimental Zoology·S GLUECKSOHN-SCHOENHEIMER

❮ Previous
Next ❯

Citations

Sep 6, 2003·Lancet·Judith G Hall
Jul 29, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lutz BüngerGeoff Simm
Jun 26, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·K I AstonD T Carrell
Jan 5, 2014·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·John St ClairRichard Lathe
Aug 2, 2006·Clinical Genetics·H OstrerN A Hanley
Jul 15, 1997·Genomics·R H ReevesD E Cabin
Jun 23, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R L Gardner
May 26, 1999·The Journal of Comparative Neurology·I AbusaadI P Everall
Aug 23, 2016·Reproduction in Domestic Animals = Zuchthygiene·C J JoonèJ O Nöthling
Nov 17, 2004·Genes, Brain, and Behavior·R Lathe
Apr 7, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Ales SobekRadovan Pilka
May 11, 2021·PloS One·Ethan A BremWilliam J Israelsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.