Does motor subtype influence neurocognitive performance in Parkinson's disease without dementia?

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
E LyrosP Papathanasopoulos

Abstract

The postural instability and gait difficulty (PIGD) motor subtype has been shown to represent a risk factor for development of dementia in Parkinson's disease. Whether this relationship extends to a more subtle cognitive dysfunction in patients is less clear. Therefore, we administered a battery of selected neuropsychological tests to two groups of non-demented patients with mild to moderate disease classified either as PIGD or as non-PIGD subtype and to a group of healthy controls. Groups were matched on potential confounders of neuropsychological performance. No significant differences were revealed between the two groups of patients in the performance of any of the administered neuropsychological tests. However, relative to controls there was a tendency towards a differential pattern of cognitive dysfunction. The PIGD group had slower performance in a test of psychomotor speed and cognitive flexibility, whilst the non-PIGD group performed worse in measures of verbal learning and visuo-spatial perception. In conclusion, the PIGD subtype was not associated with more severe cognitive deficits and may to a certain extent share common mechanisms of cognitive dysfunction with non-PIGD subtypes. Diverse pathological processes howev...Continue Reading

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Citations

Sep 6, 2011·Journal of Neural Transmission·Hana Přikrylová VranováPetr Kaňovský
Aug 5, 2011·Journal of the International Neuropsychological Society : JINS·Daniel R SeichepineAlice Cronin-Golomb
Sep 18, 2009·Brain : a Journal of Neurology·M SelikhovaA J Lees
Aug 25, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Scott A WylieCarol A Manning
Jun 26, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jong Moon LeeKun Woo Park
Jun 11, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Magdalena Eriksson DomellöfLars Forsgren
Jun 29, 2011·Acta Neurologica Scandinavica·M Flensborg DamholdtK Ostergaard
Dec 11, 2014·Journal of Neural Transmission·Talia HermanJeffrey M Hausdorff
Apr 15, 2011·Parkinsonism & Related Disorders·Michele PolettiUbaldo Bonuccelli
Aug 15, 2014·Frontiers in Aging Neuroscience·Rakhee KrishnaAhmed A Moustafa
Apr 24, 2018·Journal of Motor Behavior·Carolina de Oliveira SouzaEgberto Reis Barbosa
Oct 17, 2017·Journal of the International Neuropsychological Society : JINS·Sarah M SzymkowiczDawn Bowers
Aug 30, 2017·Journal of the International Neuropsychological Society : JINS·Christopher TollesonScott Wylie

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