Does neuroinflammation fan the flame in neurodegenerative diseases?

Molecular Neurodegeneration
Tamy C Frank-CannonMalú G Tansey

Abstract

While peripheral immune access to the central nervous system (CNS) is restricted and tightly controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety of insults. Infections, trauma, stroke, toxins and other stimuli are capable of producing an immediate and short lived activation of the innate immune system within the CNS. This acute neuroinflammatory response includes activation of the resident immune cells (microglia) resulting in a phagocytic phenotype and the release of inflammatory mediators such as cytokines and chemokines. While an acute insult may trigger oxidative and nitrosative stress, it is typically short-lived and unlikely to be detrimental to long-term neuronal survival. In contrast, chronic neuroinflammation is a long-standing and often self-perpetuating neuroinflammatory response that persists long after an initial injury or insult. Chronic neuroinflammation includes not only long-standing activation of microglia and subsequent sustained release of inflammatory mediators, but also the resulting increased oxidative and nitrosative stress. The sustained release of inflammatory mediators works to perpetuate the inflammatory cycle, activating additional microglia, promoting their pro...Continue Reading

References

Apr 1, 1983·Archives of Neurology·L E NeeM Ebert
Sep 1, 1995·Neurobiology of Aging·L M ShafferK R Brunden
Sep 1, 1995·Neurobiology of Aging·J LiebermanA S Kling
Sep 1, 1995·Neurobiology of Aging·I R MackenzieD G Munoz
Jan 15, 1996·Journal of Neuroscience Research·M D ArdJ D Fratkin
Mar 12, 1997·JAMA : the Journal of the American Medical Association·F LoperaK S Kosik
Mar 1, 1997·Neurology·W F StewartE J Metter
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·R B BanatiS B Blunt
Nov 3, 1998·Journal of Neurochemistry·K K Kopec, R T Carroll
Jan 28, 1999·Biochemical and Biophysical Research Communications·Y KitamuraT Taniguchi
Jul 28, 1999·Seminars in Liver Disease·S L Friedman
Feb 16, 2000·Neurobiology of Aging·W C BenzingK R Brunden
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Nov 4, 2000·Neurochemical Research·W J Lukiw, N G Bazan
Nov 10, 2000·Journal of Neural Transmission·R KrügerO Riess
Feb 13, 2001·Experimental Gerontology·E J RemarqueR G Westendorp
Mar 29, 2001·Journal of Neuropathology and Experimental Neurology·E SappM DiFiglia
May 19, 2001·Experimental Neurology·S O McGuireP M Carvey
Sep 13, 2001·The European Journal of Neuroscience·X QiaoS M Paul

❮ Previous
Next ❯

Citations

Mar 23, 2013·Metabolic Brain Disease·Dagmara Mirowska-GuzelAnna Czlonkowska
May 15, 2012·Current Neurology and Neuroscience Reports·Christopher J Barnum, Malú G Tansey
Aug 27, 2013·Neuropharmacology·Kouji FukuyamaMotohiro Okada
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Melinda E Lull, Michelle L Block
Jul 8, 2011·The British Journal of Nutrition·Zhen WangAijun Hao
Oct 21, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ashley S HarmsMalú G Tansey
May 17, 2011·Nature Neuroscience·Paramita ChakrabartyTodd E Golde
Nov 30, 2011·Antioxidants & Redox Signaling·Rommy von Bernhardi, Jaime Eugenín
Apr 23, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marie-Francoise DoursoutRoger J Bick
Nov 3, 2010·Journal of Neuroinflammation·An-Gaëlle CeulemansYvette Michotte
Jun 21, 2011·Journal of Neuroinflammation·Eun Jin YangSun-Mi Choi
Aug 2, 2011·Journal of Neuroinflammation·Ingo SchulzHans-Ulrich Demuth
Jan 26, 2012·Journal of Neuroinflammation·S Sakura MinamiLi Gan
Apr 18, 2012·Journal of Neuroinflammation·Elaine L PranskiRanjita S Betarbet
Mar 16, 2011·Parkinson's Disease·Carina C Ferrari, Rodolfo Tarelli
May 22, 2013·Mediators of Inflammation·Almudena Fuster-MatanzoJesús Avila
Dec 18, 2013·European Journal of Pharmacology·Pushpender KumarPyare Lal Sharma
Jan 18, 2013·Case Reports in Medicine·Francesca TrojsiGioacchino Tedeschi
May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Mijanur RahmanMd Ibrahim Khalil
Apr 15, 2014·Brain Research Bulletin·Catarina RapôsoChristina Alves Peixoto
Jul 11, 2014·Cellular and Molecular Life Sciences : CMLS·Adelaide FernandesTeresa F Pais
Oct 10, 2014·Neurochemical Research·Simoneide S Titze-de-AlmeidaRicardo Titze-de-Almeida
Feb 9, 2012·Neurochemical Research·Jagadeesh S RaoEdmund A Reese
Aug 13, 2013·The International Journal of Neuroscience·Zhiyou CaiLiang-Jun Yan
Jun 7, 2014·Molecular and Cellular Neurosciences·Jennifer L HoodRonald B Emeson
Feb 7, 2016·Brain, Behavior, and Immunity·Tadhg CrowleyOlivia F O'Leary

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes & Huntington’s Disease

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Astrocytes & Huntington’s Disease (MDS)

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.