Does nifedipine aggravate cyclosporin--induced gingival overgrowth? An experiment in rats

Journal of Periodontology
H C ChiuD Liu

Abstract

Nifedipine (NIF) may aggravate cyclosporin A (CsA)-induced gingival overgrowth because the potentiated gingival overgrowth has been observed in the patients treated with CsA and NIF. The purpose of this study was to evaluate whether NIF could aggravate the CsA-induced gingival overgrowth in a rat model. Ninety male Sprague-Dawley rats were divided into 6 groups: the first group received 8 mg/kg of CsA daily by gastric feeding for 6 weeks; the second and third groups received NIF daily at a dosage of 10 or 50 mg/kg; the fourth and fifth groups received CsA (8 mg/kg) and NIF (10 or 50 mg/kg); and the sixth group received solvents as a negative control. Gingival dimensions (including bucco-lingual depth, mesio-distal width, and vertical height) were assessed bi-weekly from impressed stone models of the mandibular incisal region. At the end of the experiment, the animals were sacrificed. Following histopathological procedures, serial horizontal sections were obtained at the base of the central incisal papilla. Two tissue levels were selected for histometric analysis. Level 1 was defined as the point where the lingual gingiva embraced the bucco-lingual midpoint of the roots and the level 2 as the point where the lingual gingiva at t...Continue Reading

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Citations

Jun 12, 2010·Archives of Oral Biology·Marilene Issa FernandesPantelis Varvaki Rados
Jun 26, 2007·Brazilian Oral Research·Marilene Issa FernandesPantelis Varvaki Rado
Nov 26, 2005·Brazilian Oral Research·Fernanda de Oliveira Bello CorrêaSilvana Regina Perez Orrico
Jun 28, 2003·Journal of Periodontal Research·L C SpolidorioO P Almeida
Jan 16, 2021·Journal of Periodontal Research·Yu-Tang ChinEarl Fu

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