Does nitric oxide play a role in the aetiology of pre-eclampsia?

Placenta
L M PostovitCharles H Graham

Abstract

Although progress has been made toward our understanding of the pathophysiology of pre-eclampsia, the precise aetiology of this disease still remains an enigma. One of the hallmarks of pre-eclampsia is a failure of the extravillous cytotrophoblast cells to invade and remodel the uterine spiral arterioles during the first trimester of pregnancy. Moreover, studies suggest that the cause of this disorder may be immunological in nature. Evidence is provided here suggesting that impaired trophoblastic invasion of the spiral arterioles may be linked to the altered immunological response associated with pre-eclampsia. Previous studies by Reister et al., 1999 demonstrated a direct relationship between macrophage infiltration of the myometrial segments of spiral arterioles and reduced trophoblastic invasion in pre-eclampsia. Also, it is well established that activated macrophages produce large amounts of nitric oxide (NO). Our present findings reveal that low concentrations of NO-mimetic drugs (glyceryl trinitrate and sodium nitroprusside) inhibit the ability of trophoblast cells to penetrate through reconstituted extracellular matrix (Matrigel). This inhibition is accompanied by a reduced expression of the cell surface urokinase recept...Continue Reading

References

Mar 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F Belardelli
Oct 1, 1995·The Journal of Experimental Medicine·E K HaddadM G Baines
Jun 1, 1997·American Journal of Reproductive Immunology : AJRI·S A RobertsonK P Tremellen
Jun 1, 1997·American Journal of Reproductive Immunology : AJRI·M G BainesE K Haddad
May 13, 1999·Biochimica Et Biophysica Acta·J W Denninger, M A Marletta
Jun 23, 1999·American Journal of Reproductive Immunology : AJRI·S SaitoH Morikawa
Feb 26, 2000·Human Reproduction·O GenbacevS J Fisher
Feb 29, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·P Zhang, K Benirschke
Aug 19, 2000·Cellular and Molecular Life Sciences : CMLS·P Friedl, E B Bröcker

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Citations

Apr 1, 2005·Biology of Reproduction·Stephen J RenaudCharles H Graham
Mar 27, 2002·Current Opinion in Obstetrics & Gynecology·Jenny E Myers, Philip N Baker
Aug 22, 2008·Immunological Investigations·Stephen J Renaud, Charles H Graham
Jan 12, 2016·American Journal of Reproductive Immunology : AJRI·Fen NingGendie E Lash
Dec 17, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·O ApiO Unal
Jun 9, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Aris T PapageorghiouKypros H Nicolaides
Sep 19, 2002·Biochemical and Biophysical Research Communications·Lynne-Marie PostovitJohn S Elce
Aug 21, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Qiongjie ZhouXiaotian Li
Dec 23, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Walter PlasenciaJose A Garcia-Hernandez
Dec 8, 2006·Biology of Reproduction·Stephen J RenaudCharles H Graham
Mar 15, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J Moodley, S S Gwababa

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