Does nitric oxide protect from microcirculatory disturbances in experimental acute pancreatitis in rats?

International Journal of Microcirculation, Clinical and Experimental
M DoboszZ Wajda

Abstract

The aim of the study was to investigate the potential role of nitric oxide (NO) on the microcirculation in experimental acute pancreatitis in rats. Twenty-five rats were divided into the following groups: group A (5 rats) = control; group B (5 rats) = acute pancreatitis induced by retrograde taurocholate infusion into the pancreatobiliary duct without treatment; group C (5 rats) = acute pancreatitis treated with the NO donor L-arginine; group D (5 rats) = acute pancreatitis treated with the NO synthase inhibitor N-nitro-L-arginine (L-NNA); group E (5 rats) = without pancreatitis receiving L-NNA. The animals were observed throughout 4 h. The microcirculatory values of the pancreas, liver, colon, stomach and kidney were measured by means of laser Doppler flowmetry. Three animals of group D died after the third hour of the experiment. In rats with pancreatitis, a rapid decrease in microcirculatory values was observed. The most pronounced drop in capillary blood flow within all the organs was observed in rats treated with the NO synthase inhibitor L-NNA, L-arginine administration in rats with acute pancreatitis slightly improved the microcirculatory values, although the improvement was significant in colon perfusion only. We conclu...Continue Reading

Citations

Aug 29, 2003·The Journal of Surgical Research·Magnus JohanssonLeif Jansson
Jul 1, 2008·Microvascular Research·Dirk UhlmannHelmut Witzigmann
Oct 18, 2005·American Journal of Surgery·Tamara L BerezinaGeorge W Machiedo
Jun 2, 2005·World Journal of Gastroenterology : WJG·Zhen-Hua Ma, Qing-Yong Ma
Mar 26, 2008·Pancreas·Mark E Brooke-SmithGino T P Saccone
Apr 12, 2006·The British Journal of Surgery·C M Cuthbertson, C Christophi
Jan 14, 1999·The American Journal of Physiology·R E RumbautD N Granger
Jun 11, 1999·The American Journal of Physiology·E von DobschuetzK Messmer
Jun 5, 2002·World Journal of Gastroenterology : WJG·Zong-Guang Zhou, You-Dai Chen

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