PMID: 11319666Apr 25, 2001Paper

Does obesity affect febrile responsiveness?

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
Andrei I IvanovAndrej A Romanovsky

Abstract

A decreased resistance to infection and impairments of immunity are common in obese humans and in rodents with hereditary obesity. Since brown fat thermogenesis is also suppressed in obese rodents, we hypothesized that obesity leads to a decreased febrile responsiveness. We compared the fever responses to intravenous E. coli lipopolysaccharide (10 microg/kg) between Zucker fa/fa (obese due to a defective leptin receptor) and Fa/? (lean) rats and between Otsuka Long-Evans Tokushima Fatty (OLETF; obese due to the lacking cholecystokinin-A receptor) and Long-Evans Tokushima Otsuka (lean) rats. Obesity of Zucker fa/fa and OLETF rats was verified by increased body mass and fat content, hypertriglyceridemia and hypercholesterolemia. Neither fa/fa nor OLETF animals exhibited a decreased febrile responsiveness; if anything, their fevers tended to be higher than those in their lean counterparts. Obesity per se does not lead to antipyresis.

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Citations

Feb 14, 2012·Disease Models & Mechanisms·Catherine B LawrenceElysse M Knight
Mar 27, 2009·Physiology & Behavior·Alexandre A SteinerElaine Liu
Aug 1, 2006·Neurologic Clinics·Jason C O'ConnorGregory G Freund
Feb 6, 2007·Progress in Lipid Research·Alexandre A Steiner, Andrej A Romanovsky
Jul 6, 2004·Brain Research·Naoko NonakaWilliam A Banks
Apr 25, 2009·Immunology and Allergy Clinics of North America·Jason C O'ConnorGregory G Freund
Mar 17, 2015·Cell Cycle·Eszter PakaiAndrej A Romanovsky
Sep 13, 2013·Brain, Behavior, and Immunity·Joanna PohlBarbara Woodside
Sep 15, 2007·Journal of Neurophysiology·Andrey V Olypher, Ronald L Calabrese
Apr 26, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A RomanovskyWilliam S Hunter
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Feb 19, 2016·Physiology·Christoph RummelLois M Harden
Oct 31, 2020·Temperature : Multidisciplinary Biomedical Journal·Evilin N KomegaeAlexandre A Steiner

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