Does off-pump revascularization reduce coronary endothelial dysfunction?

Journal of Cardiac Surgery
H L LazarSamuel Rivers

Abstract

Off-pump coronary revascularization (OPCAB) has been shown to reduce markers of acute inflammation but its effect on coronary endothelial function is unknown. This experimental study sought to determine whether OPCAB reduces endothelial dysfunction, compared to standard cardiopulmonary bypass (CPB) with and without the anticomplement agent soluble complement receptor-1 (sCR(1)). In 10 pigs, OPCAB was simulated by snaring the left anterior descending (LAD) artery for 15 minutes followed by 3 hours of reperfusion. On-pump revascularization was simulated in 20 pigs by 15 minutes of LAD occlusion on CPB with cold blood cardioplegic arrest followed by 3 hours of reperfusion. Ten of these animals received sCR(1) (10 mg/kg) prior to CPB. Inflammatory response was monitored by percent (%) lung water increase, wall motion scores (WMS) with transthoracic echocardiography where 4 = normal to -1 = dyskinesia, and endothelial function in the distal LAD with bradykinin-induced coronary artery relaxation using organ chamber methodology. OPCAB had no effect on lung edema (% increase = 1.7 +/- 1.4 OPCAB vs. 3.4 +/- 0.5 CPB vs. 2.3 +/- 0.9 CPB + sCR(1)) and failed to prevent wall motion changes (WMS = 2.65 +/- 0.08 OPCAB vs. 2.70 +/- 0.04 CPB vs...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Investigation·M S MulliganP A Ward
Oct 1, 1996·The Annals of Thoracic Surgery·L P PerraultP M Vanhoutte
May 16, 1998·The Annals of Thoracic Surgery·H L LazarR J Shemin
May 9, 2000·The Annals of Thoracic Surgery·R AscioneG D Angelini
Feb 24, 2001·The Annals of Thoracic Surgery·H B HanglerJ O Bonatti
Feb 24, 2001·The Annals of Thoracic Surgery·U LockowandtA Franco-Cereceda
May 23, 2002·The Annals of Thoracic Surgery·Harold L LazarSheilah A Bernard

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Citations

Jul 9, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Jacobo SilvaEnrique Rodríguez
Aug 29, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Neel R SodhaFrank W Sellke

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