PMID: 6165018Mar 1, 1981Paper

Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?

Proceedings of the National Academy of Sciences of the United States of America
T W ChangG Goldstein

Abstract

OKT3 monoclonal antibody to human T cells inhibits the target cell lysis mediated by allogeneic cytotoxic T cells and the generation of these effector cells in mixed lymphocyte culture. This marked inhibition of cell-mediated lysis is not found with other monoclonal antibodies also reactive with cell surface antigens of human T cells (OKT1, OKT4, OKT5, OKT6, OKT8, and OKT11). OKT3 antibody is mitogenic and this effect appears to require receptor activation in that it occurs at low concentrations (10(-12) M range) of OKT3 antibody, requires intact OKT3 IgG, and is inhibited by a factor(s) in human plasma. By contrast, the inhibition of allogeneic cell-mediated lysis by OKT3 antibody appears to be due to steric hindrance in that it requires higher concentrations of OKT3 antibody (10(-8) M range), Fab fragments retain approximately 10% activity, and inhibition is demonstrable in the presence of human plasma. These findings are consistent with the suggestion that OKT3 antibody reacts with the human T-cell antigen-recognition structure.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Mar 1, 1977·Cellular Immunology·P Matzinger, M J Bevan
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Dec 1, 1979·Transplantation·C F ShieldP S Russell
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·U KrawinkelK Eichmann
Mar 1, 1976·The Journal of Experimental Medicine·R C Kuppers, C S Henney
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Sep 1, 1980·Vox Sanguinis·P C Kung, G Goldstein

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Citations

Jan 1, 1990·Journal of Clinical Laboratory Analysis·T J SchroederM R First
Jul 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·D AbramowiczP Vereerstraeten
Sep 1, 1992·Transplant International : Official Journal of the European Society for Organ Transplantation·K J Parlevliet, P T Schellekens
Jan 1, 1989·Immunogenetics·H O GrundyR V Lebo
Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D J Norman, M R Leone
May 1, 1984·Journal of Clinical Immunology·A WeissJ Stobo
Jan 1, 1982·Springer Seminars in Immunopathology·J W Goding
Sep 1, 1991·Biological Trace Element Research·R J CollinsS C Latham
Mar 16, 1988·Journal of Immunological Methods·D KabelitzC Brucker
Nov 1, 1986·Molecular Immunology·R BurgerH Schaefer
Jan 1, 1983·Pharmacology & Therapeutics·W E Magee, S S Ristow
Jan 1, 1981·International Journal of Immunopharmacology·P C KungG Goldstein
Jan 1, 1981·International Journal of Immunopharmacology·T W Chang, S P Gingras
Jan 1, 1981·International Journal of Immunopharmacology·C Lau, G Goldstein
Feb 1, 1984·Human Immunology·C Rohowsky-KochanN Suciu-Foca
Mar 1, 1987·Human Immunology·H C Oettgen, C Terhorst
Oct 1, 1991·Current Opinion in Immunology·J Dantal, J P Soulillou
Apr 1, 1993·Bio/technology·A WedrychowskiT W Chang
Apr 25, 1985·The New England Journal of Medicine·O Acuto, E L Reinherz
Aug 8, 1985·The New England Journal of Medicine·UNKNOWN Ortho Multicenter Transplant Study Group
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F Sanchez-MadridT A Springer
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G F BurnsI R Mackay
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A WeissJ Stobo
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A de la HeraC Martinez
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D A CantrellM J Crumpton
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J S TrimmerV D Vacquier
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A AlcoverE L Reinherz

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