Does omentectomy in epithelial ovarian cancer affect survival? An analysis of the Surveillance, Epidemiology, and End Results database

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Leah McNallyAmer Karam

Abstract

Although omentectomy is part of the staging and treatment of epithelial ovarian cancer (EOC), its performance in a patient with a grossly normal omentum—acknowledging its role in debulking gross tumor deposits—has never been definitively shown to improve survival. Using Surveillance, Epidemiology, and End Results data from 1998 to 2010, we identified patients with EOC and assessed their age, race, year of diagnosis, tumor grade, histologic subtype, International Federation of Gynecology and Obstetrics stage, lymph node dissection, nodal findings, and performance of omentectomy. We compared disease-specific survival (DSS) based on the presence or absence of omentectomy using log-rank univariate analysis, Cox multivariate analysis, and Kaplan-Meier survival curves. A total of 20,975 patients with invasive EOC underwent surgical treatment. Initial univariate analysis indicated a lower mean DSS with performance of omentectomy. However, multivariate analysis demonstrated no significant association between DSS and performance of omentectomy (hazard ratio, 0.978; P = 0.506). The DSS was improved if lymphadenectomy was performed (hazard ratio, 0.60; P < 0.001). In recent years, there was a trend toward decreased performance of omentect...Continue Reading

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Citations

Aug 19, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marjolein KleppeRoy F P M Kruitwagen
Nov 30, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jason B Trimbos
Jan 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gloria Cordeiro VidalDenis Querleu
May 19, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Wenyan Xu, Yanfang Li
Sep 12, 2019·Aging·WonJae Lee, Honami Naora
Dec 21, 2018·The Journal of Experimental Medicine·WonJae LeeHonami Naora
Feb 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gloria Cordeiro VidalDenis Querleu
Feb 17, 2021·Clinical & Experimental Metastasis·Asha KumariKarthikeyan Mythreye

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