Abstract
Neuroendocrine response to stress stimuli is influenced by previous stimuli of different nature. The aim of the study was to test whether antecedent orthostatic stress may affect the neuroendocrine response to subsequent hypoglycemia. A group of 12 (6 men, 6 women) nonobese, healthy volunteers aged 19 to 27 y (mean 24 +/- 0.8) participated in the study in two sessions: controlled insulin-induced hypoglycemia to 2.7 mmol/L for 15 min either with or without antecedent orthostatic stress (30 min of 60 degrees head-up tilt before insulin administration). Orthostatic stress caused a significant decrease in plasma volume (-9.6%; P < 0.001) and a significant increase in plasma renin activity, aldosterone, norepinephrine (P < 0.01), and adrenocorticotropic hormone (ACTH) concentrations (P < 0.05) in all subjects. Growth hormone response to hypoglycemia was diminished in women (P < 0.01). The epinephrine response to hypoglycemia was diminished in women in comparison to men (P < 0.001), but was unaffected by antecedent orthostatic stress. Hypoglycemia failed to induce the ACTH release after its elevation during orthostatic stress. ACTH response to moderate hypoglycemia without previous orthostatic stress was evident only in men in compar...Continue Reading
References
Nov 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J E GreenleafG R Mangseth
Sep 1, 1977·Life Sciences·J D Peuler, G A Johnson
Jun 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·R Schondorf, P A Low
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·M J SotskyH Shamoon
Jan 1, 1987·Endocrinology·D JezováG B Makara
Apr 1, 1995·Journal of Applied Physiology·H G Hinghofer-SzalkayJ E Greenleaf
Dec 1, 1994·Diabetologia·A M RobinsonR B Tattersall
Aug 1, 1994·Diabetologia·C FanelliC Lalli
Mar 1, 1994·Acta Physiologica Scandinavica·D JezováM Vigas
Dec 1, 1993·Metabolism: Clinical and Experimental·M P DiamondR S Sherwin
Oct 1, 1993·Acta Physiologica Scandinavica·S MatzenJ Warberg
Apr 16, 1998·Journal of Applied Physiology·G JacobD Robertson
Jun 10, 2000·Clinical Endocrinology·T D LongP J Perry
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·S N DavisF Costa
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·P GalassettiS N Davis
Apr 25, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L KsinantovaM Vigas
Oct 16, 2002·Journal of Psychosomatic Research·Constantine Tsigos, George P Chrousos
Apr 30, 2003·Journal of Neuroendocrinology·R F SmithH Dobson
Citations
May 12, 2009·Brain Research Bulletin·T E BuddenbergB Topic
Jun 16, 2009·Physiology & Behavior·Brian M FreidenbergCheryl Frye
May 22, 2007·Stress : the International Journal on the Biology of Stress·David S Goldstein, Irwin J Kopin