Does oxidative stress play a critical role in cardiovascular complications of Kawasaki disease?

Antioxidants & Redox Signaling
Elisabetta StrafaceDonatella Pietraforte

Abstract

The aim of the present work was to evaluate the contribution of the different reactive oxidizing species to systemic oxidative stress in the whole blood of patients with Kawasaki disease (KD). This is a rare generalized systemic vasculitis typical of the early childhood characterized by inflammation and endothelial dysfunction with a high risk for cardiovascular fatal events. We found that, compared to age-matched healthy donors, blood from KD patients showed increased production of oxygen- and nitrogen-derived species as detected by electron paramagnetic resonance (EPR) spin probing with the cyclic hydroxylamine 1-hydroxy-3-carboxy-pyrrolidine. The (•)NO pathway involvement was also confirmed by the decreased concentrations of the endogenous (•)NO synthase inhibitor asymmetric dimethyl-arginine and the increased amounts of 3-nitrotyrosine in plasma. Further, increased plasma yields of the proinflammatory enzyme myeloperoxidase were also observed. The appearance of circulating red blood cell alterations typically associated with oxidative imbalance and premature aging (e.g., decrease of total thiol content, glycophorin A, and CD47 expression, as well as increase of phosphatidylserine externalization) has also been detected. Col...Continue Reading

References

Aug 17, 2006·Antioxidants & Redox Signaling·Florian LangThomas Wieder
Aug 13, 2008·Circulation·Annette L Baker, Jane W Newburger
Jan 19, 2010·Biochemical and Biophysical Research Communications·Elisabetta StrafaceDomenico Del Principe
Feb 14, 2012·Pediatric Cardiology·Kazunari KanekoShoji Tsuji
Feb 22, 2012·Pediatrics and Neonatology·Ho-Chang KuoKai-Sheng Hsieh

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Citations

Sep 24, 2013·PloS One·Jane C BurnsUNKNOWN Kawasaki Disease Global Climate Consortium
Dec 30, 2014·International Journal of Cardiology·Donatella PietraforteElisabetta Straface
Sep 17, 2013·Journal of the American Academy of Dermatology·Stephanie BayersAmy S Paller
Sep 17, 2013·Journal of the American Academy of Dermatology·Stephanie BayersAmy S Paller
Jun 13, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ken-Pen WengLuo-Ping Ger
Mar 8, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R RuotoloD Del Rio
Jan 8, 2017·Journal of Cellular and Molecular Medicine·Domenico Del PrincipeElisabetta Straface
Nov 23, 2017·Immunity & Ageing : I & a·Marco CasciaroSebastiano Gangemi
Jul 3, 2015·The Journal of Rheumatology·Manuela DI FrancoElisabetta Straface
Jul 10, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Ayşe KamanGönül Tanır
Jul 11, 2019·Current Gene Therapy·Xueyan ZhangQingnan He
Jun 25, 2020·Biomedicines·Alessio MetereGiovanni Casella
May 14, 2021·Clinical & Translational Immunology·Toshiro HaraYasunari Sakai

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Methods Mentioned

BETA
coronary artery dilation
fluorescence-activated cell-sorting
flow cytometry
ELISA

Software Mentioned

FACScan
Cell Quest

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