PMID: 8601653Apr 1, 1996Paper

Does palpability of primary cutaneous melanoma predict dermal invasion?

Journal of the American Academy of Dermatology
B F O'DonnellC Billingham

Abstract

Relatively few studies have addressed the question of whether clinical estimation of melanoma thickness by palpation can accurately predict its histologic thickness. If palpability was a reliable predictor of dermal invasion, it could be used to define the surgical margin. We sought to determine whether clinical elevation of melanoma could be used to predict the presence or absence and the degree of dermal invasion in patients with stage 1 cutaneous melanoma. Melanomas in 165 patients were categorized by one observer as flat, just palpable, palpable, or nodular. This was compared with histologic measurements of tumor thickness. Overall there was significant correlation between the degree of palpability of melanoma and the presence or absence of dermal invasion (p<0.001), Breslow thickness (p<0.0001), and Clark level (p<0.001). However, the relation between palpability and Breslow thickness for invasive melanomas less than 1 mm thick was weaker (n=62, p=0.053), and the correlation between elevation and Clark level was not significant for invasive melanomas less than 4 mm thick (n=111, p>0.999). We conclude that palpability of melanoma is an inadequate guide to the presence or absence and degree of dermal invasion in melanomas le...Continue Reading

References

Mar 1, 1992·World Journal of Surgery·S J SoongJ Y Lee
Apr 1, 1987·The Journal of Dermatologic Surgery and Oncology·A W KopfS L Gumport
Aug 1, 1984·The British Journal of Dermatology·W FunkO Braun-Falco
Jun 1, 1993·The British Journal of Surgery·G T NeadesK Horgan

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Citations

Aug 22, 2007·Archives of Dermatology·Karyn B StitzenbergRobert C Millikan
Jan 28, 1999·Journal of the American Academy of Dermatology·G ArgenzianoM Delfino
Jun 21, 2002·Clinics in Dermatology·Vincenzo De Giorgi, Paolo Carli
Oct 17, 2002·Dermatologic Clinics·Marek Elbaum
Nov 25, 2014·The British Journal of Dermatology·T González-ÁlvarezS Puig
Sep 3, 2008·Journal of the American Academy of Dermatology·Kien T TranClay J Cockerell
Apr 18, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·P CarliB Giannotti

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