PMID: 8944821Nov 1, 1996Paper

Does parallel conductance vary during systole in the human right ventricle?

Cardiovascular Research
P A WhiteA N Redington

Abstract

Right ventricular (RV) contractile performance remains poorly characterised, particularly in humans. Conductance catheter techniques have the potential to overcome the geometric difficulties in RV volume measurement that have hindered systematic studies of RV pressure volume relations. The present study examines changes in parallel conductance (Vc) that may occur during the cardiac cycle in the human right ventricle. Using signals obtained from custom-built conductance catheters, six isochronal systolic values of Vc (Vc(t)) were measured during hypertonic saline wash-in. Studies were performed in nine patients undergoing right heart catheterisation. Their ages ranged from 7 to 39 years (median = 16) and their weights ranged from 20.3 to 84.7 kg (median = 50.0 kg). Measurements of mean Vc and isochronal Vc(t) and its variability during systole were assessed. Mean Vc was measured using the Baan technique (Vc(Baan)), Vc(t) was measured from six systolic isochrones obtained during the same period of hypertonic saline wash-in. The temporal changes in Vc(t) were small (mean 5.8%, median = 4.4%, range = 0.6-17.9%) of total corrected end-diastolic volume (mean maximal variation of 7.7 ml). The value of Vc(t) obtained at dp/dtmax (mean ...Continue Reading

Citations

Jan 29, 2005·Annals of Biomedical Engineering·Ghassan S KassabHans Gregersen
Jan 31, 2015·Heart Failure Reviews·Richard G AxellPaul A White
Jul 4, 2001·The Journal of Thoracic and Cardiovascular Surgery·M H DantonL Aklog
Sep 9, 2011·IEEE Transactions on Bio-medical Engineering·Christakis ConstantinidesRichard James Mean
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ghassan S KassabHans Gregersen

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