Does Partner Selection Mediate the Relationship Between School Attendance and HIV/Herpes Simplex Virus-2 Among Adolescent Girls and Young Women in South Africa: An Analysis of HIV Prevention Trials Network 068 Data

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Marie C D StonerAudrey Pettifor

Abstract

School attendance prevents HIV and herpes simplex virus-2 (HSV-2) in adolescent girls and young women, but the mechanisms to explain this relationship remain unclear. Our study assesses the extent to which characteristics of sex partners, partner age, and number mediate the relationship between attendance and risk of infection in adolescent girls and young women in South Africa. We use longitudinal data from the HIV Prevention Trials Network 068 randomized controlled trial in rural South Africa, where girls were enrolled in early adolescence and followed in the main trial for more than 3 years. We examined older partners and the number of partners as possible mediators. We used the parametric g-formula to estimate 4-year risk differences for the effect of school attendance on the cumulative incidence of HIV/HSV-2 overall and the controlled direct effect (CDE) for mediation. We examined mediation separately and jointly for the mediators of interest. We found that young women with high attendance in school had a lower cumulative incidence of HIV compared with those with low attendance (risk difference = -1.6%). Partner age difference (CDE = -1.2%) and the number of partners (CDE = -0.4%) mediated a large portion of this effect. I...Continue Reading

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Sep 14, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marie C D StonerAudrey Pettifor

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Citations

Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Meghna RanganathanAudrey Pettifor
Jan 7, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hillary M TopazianAudrey Pettifor
Jul 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine B RucinskiStefan D Baral
Dec 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marie C D StonerAudrey Pettifor

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