Does perfluorooctane sulfonate (PFOS) act as chemosensitizer in zebrafish embryos?

The Science of the Total Environment
Susanne KeiterTill Luckenbach

Abstract

Earlier studies have shown that perfluorooctane sulfonate (PFOS) increases the toxicity of other chemicals by enhancing their uptake by cells and tissues. The present study aimed at testing whether the underlying mechanism of enhanced uptake of chemicals by zebrafish (Danio rerio) embryos in the presence of PFOS is by interference of this compound with the cellular efflux transporter Abcb4. Modifications of uptake/clearance and toxicity of two Abcb4 substrates, the fluorescent dye rhodamine B (RhB) and vinblastine, by PFOS were evaluated using 24 and 48h post-fertilization (hpf) embryos. Upon 90min exposure of 24hpf embryos to 1μM RhB and different PFOS concentrations (3-300μM) accumulation of RhB in zebrafish was increased by up to 11.9-fold compared to controls, whereas RhB increases in verapamil treatments were 1.7-fold. Co-administration of PFOS and vinblastine in exposures from 0 to 48hpf resulted in higher vinblastine-caused mortalities in zebrafish embryos indicating increased uptake of this compound. Interference of PFOS with zebrafish Abcb4 activity was further studied using recombinant protein obtained with the baculovirus expression system. PFOS lead to a concentration-dependent decrease of the verapamil-stimulated A...Continue Reading

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Mar 8, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Christian KropfKarl Fent
Feb 9, 2017·Archives of Toxicology·Thomas Efferth, Manfred Volm
Mar 7, 2019·Frontiers in Cell and Developmental Biology·Valérie BercierCéline Revenu
Aug 20, 2021·Environmental Science and Pollution Research International·Bettie CormierSteffen H Keiter

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