Does periacetabular osteotomy have depth-related effects on the articular cartilage of the hip?

Clinical Orthopaedics and Related Research
Andreas M HingsammerYoung-Jo Kim

Abstract

Osteoarthritis may result from abnormal mechanics leading to biochemically mediated degradation of cartilage. In a dysplastic hip, the periacetabular osteotomy (PAO) is designed to normalize the mechanics and our initial analysis suggests that it may also alter the cartilage biochemical composition. Articular cartilage structure and biology vary with the depth from the articular surface including the concentration of glycosaminoglycans (GAG), which are the charge macromolecules that are rapidly turned over and are lost in early osteoarthritis. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive measurement of cartilage GAG content. The dGEMRIC index represents an indirect measure of GAG concentration with lower values indicating less GAG content. GAG content can normally vary with mechanical loading; however, progressive loss of GAG is associated with osteoarthritis. By looking at the changes in amounts of GAG in response to a PAO at different depths of cartilage, we may gain further insights into the types of biologic events that are occurring in the joint after a PAO. We (1) measured the GAG content in the superficial and deep zones for the entire joint before and after PAO; and (...Continue Reading

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Citations

Dec 19, 2013·PloS One·Kamran ShamaeiAaron M Dollar
Apr 19, 2019·Clinical Orthopaedics and Related Research·Florian SchmaranzerGuoyan Zheng
Oct 7, 2016·Clinical Orthopaedics and Related Research·Florian SchmaranzerMoritz Tannast
Nov 2, 2019·The Bone & Joint Journal·Tetsuya EnishiShunji Nakano

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