Does polycystic ovary syndrome affect cognition? A functional magnetic resonance imaging study exploring working memory

Fertility and Sterility
Remi S SolemanCornelis B Lambalk

Abstract

To study effects of overexposure to androgens and subsequent antiandrogenic treatment on brain activity during working memory processes in women with polycystic ovary syndrome (PCOS). In this longitudinal study, working memory function was evaluated with the use of functional magnetic resonance imaging (MRI) in women with PCOS before and after antiandrogenic treatment. Department of reproductive medicine, university medical center. Fourteen women with PCOS and with hyperandrogenism and 20 healthy control women without any features of PCOS or other hormonal disorders. Antiandrogenic hormone treatment. Functional MRI response during a working memory task. At baseline women with PCOS showed more activation than the control group within the right superior parietal lobe and the inferior parietal lobe during task (all memory conditions). Task performance (speed and accuracy) did not differ between the groups. After antiandrogenic treatment the difference in overall brain activity between the groups disappeared and accuracy in the high memory load condition of the working memory task increased in women with PCOS. Women with PCOS may need additional neural resources during a working memory task compared with women without PCOS, suggest...Continue Reading

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Citations

May 30, 2017·Frontiers in Neuroendocrinology·Aleisha M Moore, Rebecca E Campbell
Mar 10, 2016·Fertility and Sterility·Courtney A Marsh
Oct 18, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Deepika Velusami, Sivaranjini Sivasubramanian
Apr 21, 2020·Endocrine Reviews·Elisabet Stener-VictorinDavid H Abbott
Oct 5, 2019·Journal of the Endocrine Society·Brittany Y JarrettMarla E Lujan
Apr 27, 2019·Frontiers in Endocrinology·Marcia H RatnerDavid H Farb
Nov 18, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Eleni ArmeniIrene Lambrinoudaki
May 21, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Grzegorz FranikPaweł Madej
Nov 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Basak Ozgen Saydam, Bulent Okan Yildiz

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