Does polydeoxyribonucleotide has an effect on patients with tendon or ligament pain?: A PRISMA-compliant meta-analysis.

Medicine
Dae-Won GwakDonghwi Park

Abstract

Pain in the tendons or ligaments is extremely common, accounting for 30% of the causes of visiting general practitioners. Polydeoxyribonucleotide (PDRN) is emerging as a new treatment for musculoskeletal pain. However, the effects of PDRN in patients with tendon or ligament pain are unclear. Therefore, this study aimed to determine the impact of PDRN in patients with tendon or ligament pain through a meta-analysis. Electronic literature search of PubMed, Embase, SCOPUS, and Cochrane Library databases of all articles on PDRN treatment for patients with tendon or ligament pain published in the English language from inception until January 31, 2020. The search identified 262 citations. One randomized controlled trial and 3 retrospective observational studies were included. Pain due to tendon or ligament disorders showed significant improvement after PDRN injection (standardized mean difference [SMD] = -1.43, 95% confidence interval [CI] = -1.80 to -1.06, P < .00001). In the subanalysis of patients with rotator cuff tendinopathy, rotator cuff tendinopathy-induced pain significantly improved (SMD = -2.34, 95% CI = -3.61 to -1.07, P = .0003) after PDRN injection. However, there was no difference in shoulder pain and disability index ...Continue Reading

References

May 1, 2008·Clinical Orthopaedics and Related Research·Brett M Andres, George A C Murrell
Oct 29, 2009·Cardiovascular & Hematological Agents in Medicinal Chemistry·Domenica AltavillaFrancesco Squadrito
Apr 11, 2012·Journal of Athletic Training·Jingzhen YangErin Heiden
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Sakshi Sachdeva, Monika Gupta
Sep 5, 2013·International Journal of Experimental Pathology·Natasha Agabalyan
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
May 12, 2017·Frontiers in Pharmacology·Francesco SquadritoDomenica Altavilla
Nov 3, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shin Hyuk KangSeung Hwan Chang
May 18, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Kyoungho RyuSung Hyun Lee
Nov 2, 2019·Annals of Physical and Rehabilitation Medicine·Dong Rak Kwon, Yong Suk Moon

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