Does positive selection determine the B cell repertoire?

European Journal of Immunology
S Hachemi-RachediP Sanchez

Abstract

To know whether each newly formed B cell has an equal chance of survival in the organism, we analyzed the composition of the B cell repertoire of extremely limited diversity by generating mu-transgenic kappa-knockout mice. Surprisingly, in both types of mice studied, the B cell repertoire is mainly composed of cells expressing the mu-transgene-encoded chain associated with only one out four available lambda types depending on the mu transgene. Moreover, B cell differentiation cultures in vitro show that newly formed B cells can express the various lambda types regardless of the presence or absence of the mu transgenes. These results show a drastic impact of the heavy chain on the lambda light chain repertoire expressed in the periphery. The overexpression of a unique heavy/light chain pairing therefore results from selective processes. The immature B cells may be positively selected to provide the immunocompetent B cells in the periphery.

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Citations

Apr 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olga KalininaMartin G Weigert
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M H LevineM J Shlomchik
Sep 29, 2000·International Immunology·P SanchezC Kanellopoulos-Langevin
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J LeeP E Lipsky
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naoki KanayamaHitoshi Ohmori
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S P FitzsimmonsM A Shapiro
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas T Su, David J Rawlings
Feb 14, 2004·Immunological Reviews·Thomas T SuDavid J Rawlings

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