Does pregnancy contribute to systemic right ventricular dysfunction in adults with an atrial switch operation?

Heart, Lung & Circulation
Dominica ZentnerLeeanne Grigg

Abstract

To determine whether pregnancy might impact adversely on long-term outcomes in adults post an atrial switch repair on the background of data demonstrating an increased rate of heart failure and death in these adults with systemic right ventricles. We retrospectively analysed our adult population with an atrial switch repair for transposition of the great arteries to see whether any differences in outcomes (sudden cardiac death, heart failure admissions, use of heart failure medications) existed between women who had and women who had not undergone pregnancy. Controls from the remaining population (transposition of the great arteries and atrial switch operation women) were elected as long as their year of birth fell into the year of birth range seen in the patient group. In women with transposition of the great arteries who have had an atrial switch repair, the long-term occurrence of sudden cardiac death and clinical heart failure (defined as a need for prescription of anti-failure medications or heart failure admissions) appears to be increased. Pregnancy may have an adverse effect on long-term outcomes in women with systemic right ventricles.

References

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Aug 2, 2001·Circulation·S C SiuUNKNOWN Cardiac Disease in Pregnancy (CARPREG) Investigators
Jul 21, 2004·Journal of the American College of Cardiology·Antoine GuédèsAnnie Dore
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Citations

Feb 3, 2016·International Journal of Cardiology·Dominica ZentnerYves d'Udekem
Feb 27, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ewa KowalikPiotr Hoffman
May 6, 2014·Current Problems in Cardiology·Vera Regitz-ZagrosekPetronella G Pieper
Jul 3, 2015·British Journal of Sports Medicine·Ruben BarakatAlejandro Lucia
Feb 3, 2015·American Heart Journal·Marlies A M KampmanUNKNOWN ZAHARA II investigators
Apr 14, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Magdalena LipczyńskaPiotr Hoffman
Jul 23, 2016·Journal of the American College of Cardiology·Uri ElkayamCandice K Silverside
Apr 7, 2018·Korean Circulation Journal·Koichiro Niwa
Apr 11, 2018·Obstetric Medicine·Emily MoroneyDominica Zentner
Sep 17, 2019·Heart, Lung & Circulation·Tyson A FrickeDominica Zentner
Apr 7, 2021·Journal of the American Heart Association·Isabel HardeeMatthew E Oster

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