Does preoperative neoadjuvant chemotherapy impact short-term surgical outcomes in patients with locally advanced colon cancer?

International Journal of Colorectal Disease
Ryan SilvaValentine Nfonsam

Abstract

Preoperative neoadjuvant chemotherapy (NAC) for colon cancer in advanced stages is associated with improved outcomes and tumor regression. The aim of our study was to identify outcomes in patients with colon cancer who received preoperative NAC. A 4-year analysis of the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) was performed. We included patients with locally advanced colon cancer (non-metastatic T3, T4 with or without nodal involvement) who underwent colon cancer resection. Patients were stratified into two groups (NAC and No-NAC). Our outcome measures were anastomotic leaks, hospital length of stay (LOS), 30-day complications, 30-day mortality, and 30-day readmissions. We performed a multi-variable logistic regression analysis. We analyzed 90,055 patients of which 7694 (NAC: 7.8 % (n = 599) and No-NAC: 92.2% (n = 7095)) met the inclusion criteria and included in the analysis. Mean age was 67 ± 13 years, 51% were males, and 72% were whites. Patients in the NAC group were more likely to be younger (60 ± 12 years vs. 68 ± 13 years, p < 0.01) and males (62% vs. 50%, p < 0.01) compared to No-NAC. On regression analysis, preoperative NAC was independently associated with higher odds of a...Continue Reading

References

Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Jul 21, 2009·Diseases of the Colon and Rectum·Roland S CronerJonas Goehl
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S DigheG Brown
Dec 12, 2012·Digestive Diseases·J O Larkin, P R O'Connell
Nov 1, 2013·Journal of the National Cancer Institute·Carolyn M RutterDeborah Schrag
Nov 28, 2013·Scandinavian Journal of Gastroenterology·Anne NørgaardSøren R Rafaelsen
Apr 11, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Andrea CercekLeonard B Saltz
Apr 30, 2015·Acta Oncologica·Anders JakobsenJesper Vilandt
Feb 9, 2017·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Fangqi LiuYe Xu
Aug 15, 2017·Acta Radiologica Open·Claus DamSøren Rafael Rafaelsen
Sep 22, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ahmed DehalMelanie Goldfarb
Feb 2, 2018·Journal of Clinical Medicine·Benjamin E AnsaSelina A Smith
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Nov 14, 2019·Annals of Surgical Oncology·Rodney E WegnerAlexander V Kirichenko
Feb 6, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K StormarkH Kørner
Aug 17, 2020·World Journal of Surgical Oncology·Marius KryzauskasTomas Poskus

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Citations

Aug 13, 2021·Scientific Reports·Yuexiang LiangJingquan Li

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