Does preservation of the sub-valvular apparatus during mitral valve replacement affect long-term survival and quality of life? A Microsimulation Study.

Journal of Cardiothoracic Surgery
Christopher RaoThanos Athanasiou

Abstract

Techniques to preserve the sub-valvular apparatus in order to reduce morbidity and mortality following mitral valve replacement have been frequently reported. However, it is uncertain what impact sub-valvular apparatus preservation techniques have on long-term outcomes following mitral valve replacement. This study investigated the effect of sub-valvular apparatus preservation on long-term survival and quality of life following mitral valve replacement. A microsimulation model was used to compare long-term survival and quality-adjusted life years following mitral valve replacement after conventional valve replacement and sub-valvular apparatus preservation. Probabilistic sensitivity analysis and alternative analysis were performed to investigate uncertainty associated with the results. Our Analysis suggests that patients survive longer if the sub-valvular apparatus are preserved (65.7% SD 1.5%, compared with 58.1% SD 1.6% at 10 years). The quality adjusted life years gained over a 10 year period where also greater after sub-valvular apparatus preservation. (6.54 QALY SD 0.07 QALY, compared with 5.61 QALY, SD 0.07 QALY). The superiority of preservation techniques was insensitive to patient age, parameter or model uncertainty. Th...Continue Reading

References

Jul 1, 1979·The Annals of Thoracic Surgery·J I MillerC R Hatcher
Jan 1, 1992·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P K GhoshP K Mittal
Jan 1, 1994·Scandinavian Journal of Thoracic and Cardiovascular Surgery·T W DubielE Cadavid
Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·G TarelliE Respighi
Mar 1, 1994·The Annals of Thoracic Surgery·E A Rose, M C Oz
Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·U StraubE Gams
May 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·G AsimakopoulosK M Taylor
Feb 25, 1998·The Journal of Thoracic and Cardiovascular Surgery·E A GrossiS B Colvin
Apr 7, 1999·Current Opinion in Cardiology·M J Reardon, T E David
Dec 29, 1999·The Journal of Thoracic and Cardiovascular Surgery·T M YauT E David
Jan 4, 2001·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·K KiraliC Yakut
Jul 24, 2001·The Annals of Thoracic Surgery·J M Jones, M A Sarsam
Sep 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E F LewisL W Stevenson
Nov 21, 2002·The Annals of Thoracic Surgery·Michael A BorgerTirone E David
May 20, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·John P A PuvimanasingheAd J J C Bogers
Sep 12, 2003·The New England Journal of Medicine·James LubitzHarold Lentzner
Oct 1, 1961·Annals of Surgery·A STARR, M L EDWARDS
Sep 23, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hideki Sasaki, Kenji Ihashi
Aug 23, 2005·Asian Cardiovascular & Thoracic Annals·Nagarajan MuthialuMuralidharan Srinivasan
Aug 27, 2005·The Annals of Thoracic Surgery·John P A PuvimanasingheAd J J C Bogers
Jan 3, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·John P A PuvimanasingheAd J J C Bogers
Feb 24, 2006·Health Economics·Mark J SculpherChris McCabe
Nov 30, 2006·Psychology, Health & Medicine·UNKNOWN The National Institute Of Mental Health Multisite HIV Prevention Trial Group
Dec 19, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jeffrey Shuhaiber, Robert J Anderson
Feb 16, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Zehra JafferySanjaya Khanal
Aug 9, 2007·JAMA : the Journal of the American Medical Association·John T SchousboeKristine E Ensrud

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Citations

Apr 19, 2011·Heart, Lung & Circulation·Christopher RaoThanos Athanasiou
Dec 21, 2016·Annals of Biomedical Engineering·Amir H KhalighiMichael S Sacks
May 28, 2011·Expert Review of Cardiovascular Therapy·Michael O MurphyThanos Athanasiou

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