Does pretreatment seropositivity to human papillomavirus have prognostic significance for head and neck cancers?

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Elaine M SmithLubomir P Turek

Abstract

Human papillomavirus (HPV) is a risk factor for head and neck cancers (HNC), yet HPV-associated tumors have better prognosis than HPV-negative tumors. We evaluated whether pretreatment presence of antibodies to HPV capsids [virus-like particles (VLP)] or to HPV-16 oncoproteins E6 and E7 was a predictor of HPV-positive HNC and clinical outcomes. Sera from 156 HNC patients were tested for antibodies to HPV-16-derived antigens using ELISA. HPV-16 in tumors was evaluated by PCR and DNA sequencing. HPV-16 antibodies were found in 33% with HPV-16 VLP, 21% with HPV-16 E6, and 21% with E7. HPV-16 was detected in 26% of tumors. There was a strong correlation between detection of HPV-16 tumor DNA and antibodies to HPV-16 E6 or E7 (kappa = 0.7) but not to HPV-16 VLP (kappa = 0.4). Multivariate analyses showed significantly better disease-specific survival in seropositive HPV-16 VLP [hazard ratio (HR), 0.4; 95% confidence interval (95% CI), 0.1-0.9], HPV-16 E6 (HR, 0.1; 95% CI, 0.02-0.5), and HPV-16 E7 (HR, 0.3; 95% CI, 0.1-0.9) cases. Less disease recurrence occurred among those with antibodies to both E6 and E7 compared with those negative to both (P = 0.003). There was better disease-specific survival in patients who were E6 positive at...Continue Reading

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Citations

Apr 20, 2010·Cancer Causes & Control : CCC·Elaine M SmithLubomir P Turek
Jul 13, 2012·Head and Neck Pathology·Tatyana IsayevaMargaret Brandwein-Gensler
Jun 10, 2010·The New England Journal of Medicine·Douglas R Lowy, Karl Munger
Sep 20, 2012·Cancer Research·Caihua LiangKarl T Kelsey
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Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Elaine M SmithLubomir P Turek
Apr 8, 2014·International Journal of Cancer. Journal International Du Cancer·Christian R SalazarNicolas F Schlecht
Jun 14, 2015·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Veronica L IrvinRobert M Kaplan
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Sep 27, 2019·Frontiers in Oncology·Panagiota EconomopoulouAmanda Psyrri
Sep 24, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Pauline Zaenker, Melanie R Ziman
Jun 9, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Owen M WilkinsBrock C Christensen
Feb 13, 2021·Frontiers in Oncology·Adrian von WitzlebenChristian H Ottensmeier

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