Does prolonged implantation of depth electrodes predispose the brain to kindling?

Brain Research
W LöscherC Rundfeldt

Abstract

Chronically implanted depth electrodes are widely used for the study of electrical signals generated in deep cerebral locations and for electrical stimulation of such locations. Although the effects of lesions resulting from electrode implantation are generally considered minimal, some reports have shown lasting neurochemical, histological, and behavioral alterations in response to such implantation. Furthermore, there is some evidence that prolonged electrode implantation may decrease the seizure threshold of the implanted region and increases the rate of kindling from this region. This prompted us to undertake a study on different periods of post-surgical delay to onset of electrical stimulation and subsequent characteristics of kindling development. Rats were implanted with a bipolar electrode in the basolateral amygdala, and the threshold for induction of focal paroxysmal activity (afterdischarge threshold, ADT) was determined after post-surgical recovery periods of either 1, 2, 4, or 8 weeks. The animals were then kindled by daily administration of an electrical stimulus until all rats exhibited fully kindled seizures. In fully kindled rats, the ADT was redetermined. Compared to animals with 1 week of electrode implantatio...Continue Reading

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Citations

Sep 1, 1997·Physiology & Behavior·U Ebert, M Koch
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Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Manja Schubert, Doris Albrecht
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Sep 12, 2017·Journal of Integrative Neuroscience·Amber L Harris BozerAi-Ling Li

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