Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of aging.

The Journal of Urology
Stacy LoebPatrick C Walsh

Abstract

Although prostate specific antigen velocity was proposed to increase the specificity of prostate specific antigen-based screening, there are little published data on the effect of differential prostate growth on prostate specific antigen velocity. If a patient presents with rising prostate specific antigen over a year or more, it would be useful to know whether such a change in prostate specific antigen could be explained by prostate growth. Thus, we investigated the relationship between changes in prostate size and prostate specific antigen changes in a large cohort of men without prostate cancer. We identified 242 men without prostate cancer from the Baltimore Longitudinal Study of Aging who had 2 or greater serial pelvic magnetic resonance imaging studies and contemporaneous prostate specific antigen measurements. In this population we used the t test, correlation coefficients, and regression analysis to examine the relationship between prostate specific antigen changes and prostate volume changes, as assessed by magnetic resonance imaging. The mean age was 55 years. During 4.2 years of median followup, the median rate of volume change was 0.6 cc per year (range -9.9 to 11.8), and the median prostate specific antigen change ...Continue Reading

References

Nov 1, 1992·Journal of Computer Assisted Tomography·A RahmouniE Zerhouni
Sep 1, 1984·The Journal of Urology·S J BerryL L Ewing
Nov 1, 1994·British Journal of Urology·M al-RimawiM A Johnson
Apr 1, 2004·Clinical Chemistry·Stephen D MikolajczykHarry G Rittenhouse
Jul 13, 2004·The New England Journal of Medicine·Anthony V D'AmicoWilliam J Catalona
Feb 12, 2005·BJU International·Denis ReyFrederic Staerman
Mar 11, 2005·Expert Opinion on Pharmacotherapy·Bob DjavanYan Kit Fong
Jul 28, 2005·JAMA : the Journal of the American Medical Association·Anthony V D'AmicoMing-Hui Chen
Feb 10, 2006·The New England Journal of Medicine·Stephen BentAndrew L Avins
May 5, 2006·The New England Journal of Medicine·Paul R Casner
Nov 2, 2006·Journal of the National Cancer Institute·H Ballentine CarterE Jeffrey Metter
Feb 14, 2007·The Journal of Urology·Stacy LoebRobert B Nadler

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