PMID: 9163778May 1, 1997Paper

Does recurrent acute pancreatitis lead to chronic pancreatitis? Sequential morphological and biochemical studies

Pancreas
C RiazH Miki

Abstract

The pathogenesis of chronic pancreatitis (CP) has been debated as to whether it is a de novo process or the consequence of acute pancreatitis (AP). We investigated whether recurrent AP in rats leads to CP, by sequential morphological and biochemical studies. Thirty male Wistar rats were fed a choline-deficient diet with intraperitoneal ethionine injections twice daily at a dose of 60 mg/100 g body weight twice weekly, and six rats were killed at 4, 6, and 8 weeks; the remaining 12 rats, followed without further treatment, were killed at 12 and 16 weeks. The pancreata from study and control groups were examined by histology, immunohistochemistry, and bio- and immunoassays. Histologically, moderate to severe intra- and perilobular fibrosis and other CP-like lesions appeared maximally at 8 weeks. Immunohistochemically, the earliest extracellular matrix change was strong fibronectin staining at 4 weeks, with a progressive increase to 8 weeks. Collagens I and III came to show strong, and collagen IV moderate, interstitial staining at 6-8 weeks. These morphological changes, however, returned to nearly normal at 16 weeks. Prolyl hydroxylase was significantly elevated at 4 and 6 weeks and normalized after 8 weeks, with no significant c...Continue Reading

Citations

Aug 2, 2008·Journal of Hepato-biliary-pancreatic Surgery·Takeo YasudaYoshikazu Kuroda
Jun 20, 2002·European Journal of Gastroenterology & Hepatology·Wiktor Bednarz, Robert Olewiński
Sep 28, 2002·European Journal of Gastroenterology & Hepatology·Tim StrateJakob R Izbicki
Sep 4, 2007·Journal of Gastroenterology and Hepatology·Akinori ShirahigeMitsune Tanimoto
Dec 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yoshifumi Takeyama
Feb 22, 2001·The Journal of Surgical Research·E K NgK M Murayama
Nov 9, 2016·AJR. American Journal of Roentgenology·Kumar SandrasegaranStuart Sherman
May 7, 2004·Journal of Clinical Gastroenterology·Esmeralda C Marginean, Dhanpat Jain
Dec 5, 2014·World Journal of Gastroenterology : WJG·Kun-Chun ChiangJun-Te Hsu
Sep 2, 1999·The Surgical Clinics of North America·P G Lankisch

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