Does reduced myocardial efficiency in systemic hypertensive-hypertrophy correlate with increased left-ventricular wall thickness?

Hypertension Research : Official Journal of the Japanese Society of Hypertension
June-Chiew HanDenis S Loiselle

Abstract

Elevated systemic blood pressure, and the attendant development of pathologic left ventricular (LV) hypertrophy, ultimately culminates in heart failure and death. In clinical studies, a reduction of myocardial efficiency has been implicated in systemic hypertensive-hypertrophy. However, it is uncertain whether reduced efficiency correlates with LV wall thickness. Hence, we performed experiments on isolated working hearts of spontaneously hypertensive rats (SHRs)-a widely-used experimental model of human hypertensive-hypertrophy. We contrasted their mechanoenergetic performance with that of Wistar controls at two ages: Adult (9 months) and Aged (post-18 months). The use of animal hearts allowed us to perform experiments over a wide range of afterloads. We found that mechanoenergetic performance (coronary and aortic flows, work output and oxygen consumption) declined with age. The peak efficiency of the Adult SHR was essentially similar to that of Control, but that for the Aged SHR was lower, compared with that of age-matched Wistar rats. All variables, including peak efficiency, obtained from the failing Aged SHR hearts (which also developed right ventricular hypertrophy), were greatly reduced. Our data reveal that peak efficien...Continue Reading

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Citations

Sep 22, 2016·World Journal of Nuclear Medicine·Semra OzdemirEmine Gazi
Apr 7, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sandor Batkai, Ariana Foinquinos
Jan 14, 2017·Physiological Reports·Alexander J WilsonIan J LeGrice
Jun 2, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nils Henrik HanssonJens Sörensen
Mar 4, 2021·Journal of Human Hypertension·Floran SahitiStefan Störk

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