Does renal dysfunction predict mortality after acute stroke? A 7-year follow-up study

Stroke; a Journal of Cerebral Circulation
Ronald S MacWalterRouling Chen

Abstract

The purpose of this study was to investigate renal function as a long-term predictor of mortality in patients hospitalized for acute stroke. This was a cohort study done in a Scottish tertiary teaching hospital. Participants included 2042 (993 male) unselected consecutive stroke patients (mean age, 73 years) admitted to hospital within 48 hours of stroke between 1988 and 1994. Follow-up was up to 7 years. Main outcome measure was all-cause mortality. The total number of deaths at the end of follow-up was 1026. Most subjects (1512) had creatinine <124 micromol/L. The mean calculated creatinine clearance was 54.8 mL/min (SD, 23 mL/min). Renal function indexes were analyzed by quartiles with Cox proportional-hazards model. Stroke survivors had higher calculated creatinine clearance and lower serum creatinine, urea, and ratios of urea to creatinine. Calculated creatinine clearance > or =51.27 mL/min significantly predicted better long-term survival in these stroke patients even after adjustment for confounders (age, neurological score, ischemic heart disease, hypertension, smoking, and diuretic use). Similarly, creatinine > or =119 micromol/L "relative risk (RR), 1.59; 95% confidence interval (CI), 1.32 to 1.92", urea 6.8 to 8.9 mm...Continue Reading

References

May 7, 2013·Clinical Neurology and Neurosurgery·Piotr SobolewskiW M Nyka
Sep 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hideki FujiiYuhei Kawano
Nov 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian CovicNorica Posta
Jul 1, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sean M Bagshaw
Aug 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George TsagalisKonstantinos Vemmos
Dec 1, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Varun AgrawalPeter A McCullough
Jan 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing XuNan Chen
Oct 19, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tanja Hojs FabjanB Pecovnik Balon
Mar 24, 2005·American Journal of Nephrology·Alain BaumelouGilbert Deray
May 27, 2009·Cerebrovascular Diseases·Elizabeth MostofskyMurray A Mittleman
Jan 1, 2009·The Libyan Journal of Medicine·Af Sawalha
Jan 10, 2014·Cerebrovascular Diseases·Cheng-Yang HsiehChih-Hung Chen
Sep 28, 2013·European Journal of Internal Medicine·Tanja Hojs Fabjan, Radovan Hojs
Nov 28, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Eva-Maria SauerMartin Köhrmann
Oct 10, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Brian P WalcottKevin N Sheth
Jun 12, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Khai P NgCharles J Ferro
Mar 20, 2012·Revista clínica española·L Mérida-RodrigoJ García-Alegría
Oct 19, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Takao HoshinoShinichiro Uchiyama
Feb 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bolanle FamakinMichael R Frankel
Oct 27, 2009·Journal of the Neurological Sciences·Chizobam Ani, Bruce Ovbiagele
Jul 23, 2013·European Journal of Clinical Investigation·Yu-Shi BaoShi-Ping Na
Apr 24, 2010·European Journal of Heart Failure·George TsagalisKonstantinos Vemmos
Mar 14, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Anne RowatMartin Dennis
Jun 29, 2015·Clinical Neurology and Neurosurgery·Shun-Wen LinWen-Yi Huang
Apr 25, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Koji TanakaHiroyuki Murai
Nov 7, 2008·International Journal of Cardiology·Louise F PorterRonald S MacWalter
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tetsuya MiyagiKazunori Toyoda
Aug 31, 2016·PloS One·Kamil ChwojnickiTomasz Zdrojewski
May 9, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fabio FabbianRoberto Manfredini
Jun 24, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Derek HaydenPeter J Kelly
Oct 17, 2017·F1000Research·Pratyush ShresthaUpendra Prasad Devkota
Jan 24, 2013·Stroke; a Journal of Cerebral Circulation·Waldo R Guerrero, James C Grotta
Aug 30, 2003·Stroke; a Journal of Cerebral Circulation·Jorge Parra RuizJosé Manuel de la Higuera Torres-Puchol
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Jul 9, 2011·Stroke; a Journal of Cerebral Circulation·Jukka PutaalaTurgut Tatlisumak

Citations

Sep 1, 1992·European Heart Journal·W B Kannel
Feb 1, 1991·Journal of Internal Medicine·P J Friedman
Aug 1, 1995·The Annals of Thoracic Surgery·A J HartzW D Johnson
Feb 15, 2000·Annals of Clinical Biochemistry·H FinneyC P Price
Sep 15, 2000·Journal of the American College of Cardiology·P A McCulloughS Borzak

Related Concepts

Kidney Function Tests
Creatinine
Creatinine Clearance Measurement
Carmol
Incidence Studies
Survival Analysis
Myocardial Ischemia
Kidney
Odds Ratio
Acute Cerebrovascular Accidents

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Stroke; a Journal of Cerebral Circulation
Gilad YahalomDavid Tanne
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
George TsagalisKonstantinos Vemmos
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Varun AgrawalPeter A McCullough
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Adrian CovicNorica Posta
© 2020 Meta ULC. All rights reserved