journal cover

Does replication groups scoring reduce false positive rate in SNP interaction discovery?

BMC Genomics

Jan 23, 2010

Marko ToplakBlaz Zupan

Abstract

Computational methods that infer single nucleotide polymorphism (SNP) interactions from phenotype data may uncover new biological mechanisms in non-Mendelian diseases. However, practical aspects of such analysis face many problems. Present experimental studies typically use SNP arrays w...read more

Mentioned in this Paper

SYN1 gene
SYN2 gene
Systems Biology
Locus
In Silico
Disease Theory of Alcohol or Other Drug Use, Abuse and Dependence
Disease Model
Single Nucleotide Polymorphism
Mentally Disabled Persons
Data Interpretation, Statistical
Paper Details
References
  • References11
  • Citations3
12

Does replication groups scoring reduce false positive rate in SNP interaction discovery?

BMC Genomics

Jan 23, 2010

Marko ToplakBlaz Zupan

PMID: 20092660

DOI: 10.1186/1471-2164-11-58

Abstract

Computational methods that infer single nucleotide polymorphism (SNP) interactions from phenotype data may uncover new biological mechanisms in non-Mendelian diseases. However, practical aspects of such analysis face many problems. Present experimental studies typically use SNP arrays w...read more

Mentioned in this Paper

SYN1 gene
SYN2 gene
Systems Biology
Locus
In Silico
Disease Theory of Alcohol or Other Drug Use, Abuse and Dependence
Disease Model
Single Nucleotide Polymorphism
Mentally Disabled Persons
Data Interpretation, Statistical
Paper Details
References
  • References11
  • Citations3
12
/papers/does-replication-groups-scoring-reduce-false/20092660