PMID: 9167507Jun 1, 1997Paper

Does risperidone improve verbal working memory in treatment-resistant schizophrenia?

The American Journal of Psychiatry
M F GreenJ Mintz

Abstract

Treatment efficacy in schizophrenia is typically defined in terms of symptom reduction. However, new antipsychotic medications could potentially have an impact on aspects of disability, such as neurocognitive deficits. The authors evaluated the effects of risperidone on verbal working memory, a memory component of theoretical interest because of its link to prefrontal activity and of practical interest because of its link to psychosocial rehabilitation. Verbal working memory of 59 treatment-resistant schizophrenic patients was assessed as part of a randomized, double-blind comparison of treatment with risperidone and haloperidol. Verbal working memory was measured under both distracting and nondistracting conditions at baseline and after 4 weeks of both fixed- and flexible-dose pharmacotherapy. Risperidone treatment had a greater beneficial effect on verbal working memory than haloperidol treatment across testing conditions (with and without distraction) and study phases (fixed and flexible dose). The treatment effect remained significant after the effects of benztropine cotreatment, change in psychotic symptoms, and change in negative symptoms were controlled. Neither benztropine status nor symptom changes were significantly r...Continue Reading

Citations

Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·G D HoneyT Sharma
Jun 1, 2000·Journal of Clinical Psychopharmacology·T SumiyoshiH Y Meltzer
Mar 17, 2001·International Clinical Psychopharmacology·J Kane
Jun 14, 2003·The Cochrane Database of Systematic Reviews·R H HunterF Song
Sep 25, 2003·The Journal of Nervous and Mental Disease·Yechiel LevkovitzEttie Grauer
Jan 1, 2004·Bipolar Disorders·Glenda Macqueen, Trevor Young
Jan 13, 2005·European Archives of Psychiatry and Clinical Neuroscience·Ann-Christine EhlisAndreas J Fallgatter
Dec 8, 2004·Journal of Psychopharmacology·Kristi A SaccoTony P George
Jun 20, 2006·European Archives of Psychiatry and Clinical Neuroscience·Alp UçokHatice Atli
Jul 17, 2007·European Archives of Psychiatry and Clinical Neuroscience·Michael RiedelHans-Jürgen Möller
Nov 16, 2007·Journal of Clinical Psychopharmacology·Simon A SurguladzeAnthony S David
Apr 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Andrei SzökeMarion Leboyer
Sep 4, 2008·Psychopharmacology·Cherrie Galletly
Dec 22, 2009·Expert Review of Neurotherapeutics·S Kristian HillJohn A Sweeney
Feb 5, 2011·Journal of Psychopharmacology·Thomas R E Barnes, UNKNOWN Schizophrenia Consensus Group of British Association for Psychopharmacology
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Adib Essali, Ghassan Ali
Jul 28, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alkomiet HasanUNKNOWN World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Treatment Guidelines for Schizophrenia
Jan 1, 2008·International Journal of Psychiatry in Clinical Practice·Yu-Ting WangYi-Cheng Liao
Jan 1, 1999·International Journal of Psychiatry in Clinical Practice·D Lecompte, R F Cookson
Nov 19, 2003·Journal of Clinical Psychopharmacology·Janusz K RybakowskiAlina Borkowska
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·H Y MeltzerR Kessler
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Raquel E GurRuben C Gur
Sep 18, 2001·Current Psychiatry Reports·P F BuckleyB Singer
Jun 13, 2003·The Journal of Head Trauma Rehabilitation·Elie Paul ElovicJoseph H Ricker
Sep 2, 2003·International Journal of Geriatric Psychiatry·Philip D HarveyGeorges Gharabawi
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Vera Bubenikova-ValesovaKarel Vales
Mar 20, 2008·Journal of Developmental and Behavioral Pediatrics : JDBP·George T CaponeHeather Kammann
Feb 8, 2007·CNS Drugs·Peter F BuckleyWilliam C Wirshing
Jun 29, 2007·Human Psychopharmacology·Janusz K RybakowskiAlina Borkowska
Sep 14, 2007·European Addiction Research·Luis SanJose Martinez-Raga
Dec 29, 2000·The Australian and New Zealand Journal of Psychiatry·D VelakoulisC Pantelis
May 4, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·O Blin
Nov 29, 2002·American Journal of Medical Genetics·Ming T TsuangStephen V Faraone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here