PMID: 15237119Jul 9, 2004Paper

Does routine blood bone biochemistry predict vitamin D insufficiency in elderly patients with low-velocity fractures?

Journal of Orthopaedic Surgery
S K SinghC R Williams

Abstract

Vitamin D deficiency impairs bone mineralisation and can predispose individuals to fractures. This study aimed at testing whether measurement of plasma calcium, alkaline phosphatase, and phosphate levels could detect vitamin D insufficiency. During a 10-week winter period from December 2000 to February 2001, all elderly patients presenting to a general hospital in Brighton--British seaside town--with a fracture of the proximal femur and without known bone mineralisation problems were invited to participate in the study. 23 (63.9%) of the 36 eligible patients had insufficient levels of vitamin D, with a plasma concentration of less than 30 nmol/L. The mean parathyroid hormone level was 56 pg/mL (range, 12-193 pg/mL). 11 of the 36 patients had an elevated level of parathyroid hormone were insufficient in vitamin D. The mean plasma concentration of calcium was 2.30 mmol/L (range, 2.05-2.98 mmol/L). The mean phosphate level was 0.98 mmol/L (range, 0.40-1.79 mmol/L), and the mean alkaline phosphatase level was 91 IU/L (range, 46-127 IU/L). There was poor correlation between vitamin D insufficiency and plasma calcium, alkaline phosphatase, or phosphate levels. Plasma calcium, alkaline phosphatase, and phosphate testing cannot detect ...Continue Reading

References

Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Oct 1, 1985·The Journal of Clinical Investigation·J MacLaughlin, M F Holick
Feb 1, 1985·Acta Orthopaedica Scandinavica·J A FalchU Slungaard
Mar 1, 1995·The American Journal of Clinical Nutrition·M F Holick
Mar 25, 1999·Calcified Tissue International·S T HadenM S LeBoff
May 5, 1999·JAMA : the Journal of the American Medical Association·M S LeBoffJ Glowacki
Aug 15, 2002·The Journal of Bone and Joint Surgery. American Volume·Michael J GardnerJoseph M Lane

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Citations

Oct 2, 2012·Indian Journal of Clinical Biochemistry : IJCB·Aysha Habib Khan, Lena Jafri
Oct 4, 2005·Current Medical Research and Opinion·S J GallacherT Dixon

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