Does S100B have a potential role in affective disorders? A literature review

Nordic Journal of Psychiatry
Hilda Kroksmark, M Vinberg

Abstract

S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders. To review the literature investigating the role of S100B in patients with affective disorders. A systematic review of original English language studies investigating S100B in serum, cerebrospinal fluid, plasma and lymphocytes, in patients with affective disorders, was conducted. The literature search was conducted within the PubMed database. Effect sizes were calculated to adjust for systematic measurement effects. Twenty studies were included, with a total of 1292 participants. Of these, 398 patients had or have had depressive disorder, 301 patients had bipolar disorder and 593 were healthy controls. S100B levels in serum were consistently elevated in studies with statistically significant results which investigated acute affective episodes (comprising major depressive episode in major depressive disorder, and both manic and depressive episodes in patients with bipolar disorder), in comparison to healthy controls. There were few studies assessing S100B levels in cerebrospinal fluid, plasma or lymphocytes, and these had inconsistent results. The results indicated that elevated S100B levels might be associat...Continue Reading

References

Aug 8, 2001·Neuropsychobiology·H J GrabeH J Freyberger
Sep 5, 2001·Journal of Affective Disorders·M RothermundtH Kirchner
May 15, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R Machado-VieiraD O Souza
May 22, 2002·Brain Research·M KapuralD Janigro
Sep 28, 2002·Neuroreport·Matthias L SchroeterIngolf E Blasig
Mar 20, 2003·Microscopy Research and Technique·Matthias RothermundtVolker Arolt
Jul 31, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Volker AroltMatthias Rothermundt
Sep 8, 2006·Journal of Psychiatric Research·Ana Cristina AndreazzaCarlos Alberto Gonçalves
May 26, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·S RocheP McKeon
Apr 24, 2008·Journal of Affective Disorders·Matthias L SchroeterIngolf E Blasig
Nov 6, 2009·Aging & Mental Health·Andreana BenitezLeigh Murray
Dec 15, 2010·Journal of Affective Disorders·Matthias L SchroeterKarsten Mueller
Feb 27, 2013·Psychiatry and Clinical Neurosciences·Silvia Yelmo-CruzPedro Abreu-González
May 25, 2013·Current Drug Targets·Matthias L SchroeterKarsten Mueller
Mar 19, 2014·Journal of Psychiatric Research·Matthias L SchroeterKarsten Mueller
Apr 4, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joel JakobssonMikael Landén
Sep 30, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Frank Martin SchmidtPeter Schönknecht
Dec 4, 2014·Metabolism: Clinical and Experimental·Madhu Kalia, Jorge Costa E Silva
Feb 12, 2015·Journal of Psychiatric Research·Tatiana FalconeAmit Anand
Oct 27, 2015·Frontiers in Cellular Neuroscience·Maryna PolyakovaMatthias L Schroeter
Feb 6, 2016·CNS Neuroscience & Therapeutics·Yuan FangXia Li
Oct 25, 2016·Journal of Affective Disorders·Maria Inês da RosaJoão Quevedo
Aug 27, 2016·Nordic Journal of Psychiatry·Ida Kim Wium-AndersenRoger S McIntyre
Nov 17, 2016·Psychiatria polska·Aleksandra Rajewska-Rager, Magdalena Pawlaczyk
Jan 16, 2017·Comprehensive Psychiatry·Meng-Chang Tsai, Tiao-Lai Huang
Oct 8, 2017·Neuroscience and Biobehavioral Reviews·Jairo Vinícius PintoOlavo B Amaral

❮ Previous
Next ❯

Citations

Mar 24, 2021·Nordic Journal of Psychiatry·Bürge Kabukçu BaşaySezai Üstün Aydin
May 23, 2021·Translational Psychiatry·Maike MichelDominique Endres
Jun 9, 2021·Scientific Reports·Aleksandra Rajewska-RagerMaria Skibinska

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.