Does S100B have a potential role in affective disorders? A literature review
Abstract
S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders. To review the literature investigating the role of S100B in patients with affective disorders. A systematic review of original English language studies investigating S100B in serum, cerebrospinal fluid, plasma and lymphocytes, in patients with affective disorders, was conducted. The literature search was conducted within the PubMed database. Effect sizes were calculated to adjust for systematic measurement effects. Twenty studies were included, with a total of 1292 participants. Of these, 398 patients had or have had depressive disorder, 301 patients had bipolar disorder and 593 were healthy controls. S100B levels in serum were consistently elevated in studies with statistically significant results which investigated acute affective episodes (comprising major depressive episode in major depressive disorder, and both manic and depressive episodes in patients with bipolar disorder), in comparison to healthy controls. There were few studies assessing S100B levels in cerebrospinal fluid, plasma or lymphocytes, and these had inconsistent results. The results indicated that elevated S100B levels might be associat...Continue Reading
References
Elevated serum S100B protein in drug-free bipolar patients during first manic episode: a pilot study
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