Does severe vitamin D deficiency impact obstetric outcomes in pregnant women with thyroid autoimmunity?

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Halenur Bozdag, Esra Akdeniz

Abstract

Purpose: Vitamin D plays an important role in the modulation of the immune system and anti-autoimmune activities. Autoimmune thyroid diseases related to endocrine disorders are associated with poor obstetric outcomes in pregnancy. Herein, we aimed to investigate the contribution of vitamin D hypovitaminosis to poor pregnancy outcomes in pregnant women with the positive autoimmune antibody.Materials and methods: This was a prospective case-control study that enrolled pregnant women at their first trimester. The pregnant women were divided based on thyroid antibody (TA) status (TA-positive pregnant group (TAs (+)) and negative group (TAs (-)). Vitamin D status was categorized as sufficient, insufficient, and deficient (severe and moderate).Results: A total of 283 pregnant women were enrolled in this study. A total of 219 pregnant women were assigned to the TAs (-) group and 64 to the TAs (+) group. The rate of vitamin D insufficiency was 8.7, and 7.8% in the pregnant with TAs (-), and the pregnant with TAs (+) groups, respectively. Vitamin D deficiency was highly prevalent in all groups. Specifically, the prevalence rate was 91 and 92% in the pregnant with TAs (-) and the pregnant with TAs (+) groups, respectively. Admission to t...Continue Reading

References

Nov 27, 2004·Experimental Biology and Medicine·Margherita T Cantorna, Brett D Mahon
Apr 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Roberto NegroHaslinda Hassan
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Indira Guleria, Mohamed H Sayegh
Feb 2, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elizabeth N PearceLewis E Braverman
Feb 14, 2008·Diabetes, Obesity & Metabolism·X PalomerD Mauricio
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael F HolickEdward Sauter
Aug 30, 2008·Nature Reviews. Immunology·Eleanor N Fish
Dec 25, 2008·The Journal of Clinical Endocrinology and Metabolism·Anne MerewoodMichael F Holick
Feb 12, 2009·Reproductive Sciences·John R ChallisFelice Petraglia
Jan 16, 2010·American Journal of Obstetrics and Gynecology·Jun ZhangMichael S Kramer
Mar 20, 2010·Clinical Reviews in Allergy & Immunology·Emiliana Konova
Apr 30, 2010·Current Opinion in Pharmacology·Femke BaekeChantal Mathieu
Jul 29, 2010·Obstetrics and Gynecology·Mina Abbassi-GhanavatiF Gary Cunningham
Feb 1, 2011·Cellular & Molecular Immunology·Shaye KivityYehuda Shoenfeld
Apr 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy Q LiuMartin Hewison
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Jul 15, 2011·Thyroid : Official Journal of the American Thyroid Association·Gonca TamerDamla Coksert
Oct 15, 2011·Clinical Endocrinology·Martin Hewison
May 31, 2012·Endocrine·Donald S A McLeod, David S Cooper
Aug 24, 2012·Human Reproduction·B RudickK Bendikson
Sep 28, 2012·The Journal of Clinical Endocrinology and Metabolism·Polyxeni KarakostaLeda Chatzi
Jan 23, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nujen Colak BozkurtTuncay Delibasi
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sedigheh SoheilykhahAhmad Shojaoddiny-Ardekani
Jul 17, 2013·Nutrients·Barbara PrietlKarin Amrein
Sep 3, 2013·Journal of Graduate Medical Education·Gail M Sullivan, Richard Feinn
Sep 18, 2013·International Journal of Women's Health·Abdulbari BenerNajah M Saleh
Dec 18, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·P M Catalano
Feb 20, 2014·Clinical and Experimental Immunology·L SchoberA Steinborn
Jun 21, 2014·Journal of Endocrinological Investigation·Olimpia BittermanAngela Napoli
Sep 10, 2014·The Journal of Clinical Endocrinology and Metabolism·Caroline K KramerRavi Retnakaran
Sep 27, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Serpil AydogmusGülcan Sağlam
Oct 14, 2014·Autoimmunity Reviews·Federica D'AurizioRenato Tozzoli
Nov 7, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hee-Won MoonYeo-Min Yun
Mar 24, 2015·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists
May 27, 2015·Nutrients·Mei-Yan XuQing-Bin Lu
May 31, 2015·Journal of Reproductive Immunology·Ozlem Turhan IyidirGoksun Ayvaz
Jun 23, 2015·Expert Review of Clinical Immunology·Tyler A SmithDevendra K Agrawal
Jul 8, 2015·Fertility and Sterility·Ying YangXu Ma
Sep 3, 2016·Endocrinology and Metabolism·Won Sang Yoo, Hyun Kyung Chung
Jan 7, 2017·Thyroid : Official Journal of the American Thyroid Association·Erik K AlexanderScott Sullivan
Jun 15, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Büşra YılmazErhan Çetinoğlu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.