Does sleep disruption mediate the effects of childhood maltreatment on brain structure?

European Journal of Psychotraumatology
Martin H TeicherMarisa M Silveri

Abstract

Background: Childhood maltreatment is associated with alterations in morphology of stress susceptible brain regions. Maltreatment is also known to markedly increase risk for psychopathology and to have an enduring disruptive effect on sleep. Objective: To determine whether abnormalities in sleep continuity have effects on brain morphometry and to evaluate the extent to which sleep impairments mediate the effects of maltreatment on brain structure. Method: Maltreatment and Abuse Chronology of Exposure (MACE) scale ratings, actigraph-assessed sleep and 3T MRI were obtained on N = 37 18-19-year-old participants recruited from the community (N = 34 with neuroimaging). Results: Fourteen participants had no history of maltreatment while N = 23 were exposed, on average, to 4.7 types of maltreatment. Multiplicity of maltreatment was strongly associated with reduced sleep efficiency, increased wake after sleep onset time and number/duration of awakenings, which were independent of effects of maltreatment on depression and anxiety. The most important predictors of impaired sleep were exposure to parental non-verbal emotional abuse at 9-10 years of age. Reduced sleep efficiency correlated with reduced grey matter volume in hippocampus inc...Continue Reading

References

Oct 1, 1992·Sleep·R J ColeJ C Gillin
Jul 1, 1990·Statistics in Medicine·Y Hochberg, Y Benjamini
Mar 1, 1995·Consciousness and Cognition·L S Brown
Jun 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·A SadehR M Hayden
Jan 1, 1993·Psychological Bulletin·C R BrewinI H Gotlib
Mar 1, 1995·Child Abuse & Neglect·B Sanders, E Becker-Lausen
Sep 18, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·C A GlodT Harakal
Jul 26, 2002·The Psychiatric Clinics of North America·Martin H TeicherCarryl P Navalta
Nov 25, 2003·Journal of Chemical Information and Computer Sciences·Vladimir SvetnikBradley P Feuston
Mar 5, 2004·Sleep·Warren W Tryon
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Jun 17, 2005·Journal of Pediatric Psychology·Jennie G NollFrank W Putnam
Jan 27, 2007·BMC Bioinformatics·Carolin StroblTorsten Hothorn
May 9, 2007·Archives of General Psychiatry·William E CopelandE Jane Costello
Apr 9, 2008·Archives of Pediatrics & Adolescent Medicine·Helene WernerOskar G Jenni
Jan 5, 2010·Nature Reviews. Neuroscience·Susanne Diekelmann, Jan Born
Oct 20, 2010·Psychological Methods·Kosuke ImaiDustin Tingley
Apr 27, 2012·Nature Neuroscience·Richard J Davidson, Bruce S McEwen
Jun 16, 2012·Stress and Health : Journal of the International Society for the Investigation of Stress·Valérie Schäfer, Klaus Bader
Dec 4, 2012·Nature Neuroscience·Torsten KlengelElisabeth B Binder
Jun 5, 2013·The American Journal of Psychiatry·Christine M HeimJens C Pruessner
Sep 21, 2013·Learning & Memory·Toni-Moi Prince, Ted Abel
May 6, 2015·NeuroImage·Juan Eugenio IglesiasUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 3, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Martin H Teicher, Jacqueline A Samson
Oct 7, 2016·Frontiers in Human Neuroscience·Salome KurthMonique K LeBourgeois
May 26, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michele BellesiChiara Cirelli

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

ActiLife
party
FreeSurfer
MACE
R package ‘ mediation ’ )
R
mediation
relaimpo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.