Does sleep disturbance mediate neuropsychological functioning in older people with depression?

Journal of Affective Disorders
Sharon L NaismithIan B Hickie

Abstract

Depression in older adults is associated with neuropsychological dysfunction, fronto-subcortical brain changes and sleep disturbance. Research suggests that adequate sleep is critical for many aspects of cognition including processing speed, verbal skills and memory. However, the association between sleep disturbance and neuropsychological functioning in depression has not been well evaluated. The current study therefore aimed to investigate these relationships. Forty-eight people (mean age=59.6, sd=8.2) meeting DSM-IV criteria for unipolar major depression were included for analysis. Neuropsychological assessment included assessment of processing speed, learning and memory, verbal fluency and executive functions. Early and late insomnia were defined by scores on the Hamilton Depression Rating Scale. While early insomnia was related to depression severity and poorer global cognition, late insomnia was associated with later age of depression onset, depression severity, and poorer scores on tests of verbal fluency and memory. The associations between cognition and late insomnia were not accounted for by depression severity or age of onset of disorder. This study was retrospective in nature, and did not include objective measures ...Continue Reading

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Citations

May 23, 2012·Aging & Mental Health·Joanna E McHughBrian A Lawlor
Jun 18, 2015·International Journal of Geriatric Psychiatry·Angeliki TsapanouYaakov Stern
Feb 6, 2016·Sleep Medicine·Audrey LingTze-Pin Ng
Jan 1, 2013·Archives of Gerontology and Geriatrics·Marie Carmen ValenzaGerald Valenza-Demet
Sep 18, 2009·Journal of Psychiatric Research·Larriany M GiglioFlávio Kapczinski
Mar 26, 2011·Journal of Affective Disorders·Sharon L NaismithIan B Hickie
Jul 14, 2016·Journal of Clinical and Experimental Neuropsychology·Junhong YuLei Feng
Dec 13, 2016·Traffic Injury Prevention·Ion N BeratisSokratis G Papageorgiou
Apr 2, 2014·Journal of Geriatric Psychiatry and Neurology·Andrew McKinnonSharon L Naismith
Jan 27, 2010·Journal of Geriatric Psychiatry and Neurology·David G GunnSimon J G Lewis
Apr 1, 2010·Journal of Geriatric Psychiatry and Neurology·Sharon L NaismithSimon J G Lewis
Jul 18, 2020·Journal of Alzheimer's Disease : JAD·Qing GuanHaobo Zhang
Jul 14, 2010·The Medical Journal of Australia·Jane M BurnsIan B Hickie

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