Does smoking status influence the effect of physical exercise on fibrinolytic function in healthy volunteers?

Journal of Thrombosis and Thrombolysis
Antonio Tello-MontoliuFrancisco Marín

Abstract

Exercise has been reported to simultaneously trigger and protect against sudden death, the so-called "The Paradox of Exercise". Differences in fibrinolytic function appear to exist between chronic and acute exercise. The aim of the present study was to assess the fibrinolytic system after strenuous exercise in healthy people and explored the influence of smoking habit. 23 healthy male volunteers were studied (14 non-smokers; 9 current smokers). Citrated plasma blood samples were taken before and 30 minutes after a maximal exercise treadmill test, and levels of tissue type plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PAI-1) antigen and lipoprotein-a, Lp(a), [all ELISA] were measured as indices of fibrinolytic function. Smokers had higher body mass index and higher heart rate at baseline than non smokers (p = 0.046 and p = 0.001, respectively). At baseline, smokers showed increased plasma Lp(a) levels than non smokers (p = 0.04), with no differences in t-PA and PAI-1 antigen levels. Following the exercise treadmill test, smokers had a shorter exercise duration and lower exercise capacity than non smokers (p = 0.008 and p = 0.004, respectively). This was associated with a reduction in t-PA antigen levels ...Continue Reading

References

Jun 1, 1995·British Journal of Haematology·A D Blann, D A Taberner
Jul 1, 1994·American Heart Journal·S KimuraK Shimada
Apr 1, 1997·Medicine and Science in Sports and Exercise·L HubingerF Lepre
Sep 8, 1998·Journal of Applied Physiology·M A FergusonJ L Durstine
Nov 9, 2000·The New England Journal of Medicine·B J Maron
Aug 31, 2001·Medicine and Science in Sports and Exercise·J L DurstineS G Trost
Oct 26, 2001·The American Journal of Cardiology·A J SiegelG H Tofler
Jan 5, 2002·American Heart Journal·Michele DoughtyKim Eagle
Mar 19, 2002·Hypertension·Mias PretoriusNancy J Brown
Jun 24, 2003·Thrombosis Research·Thomas HilbergHolger H W Gabriel
Oct 29, 2003·Archives of Internal Medicine·Kaeng W Lee, Gregory Y H Lip
Feb 15, 2005·International Journal of Cardiology·Antonio TelloFrancisco Sogorb

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Citations

Jul 1, 2012·Indian Journal of Clinical Biochemistry : IJCB·R Alberty, D Albertyová

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