Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure?

Journal of Applied Physiology
Thomas K AnsellPeter B Noble

Abstract

In isolated airway smooth muscle (ASM) strips, an increase or decrease in ASM length away from its current optimum length causes an immediate reduction in force production followed by a gradual time-dependent recovery in force, a phenomenon termed length adaptation. In situ, length adaptation may be initiated by a change in transmural pressure (Ptm), which is a primary physiological determinant of ASM length. The present study sought to determine the effect of sustained changes in Ptm and therefore, ASM perimeter, on airway function. We measured contractile responses in whole porcine bronchial segments in vitro before and after a sustained inflation from a baseline Ptm of 5 cmH2O to 25 cmH2O, or deflation to -5 cmH2O, for ∼50 min in each case. In one group of airways, lumen narrowing and stiffening in response to electrical field stimulation (EFS) were assessed from volume and pressure signals using a servo-controlled syringe pump with pressure feedback. In a second group of airways, lumen narrowing and the perimeter of the ASM in situ were determined by anatomical optical coherence tomography. In a third group of airways, active tension was determined under isovolumic conditions. Both inflation and deflation reduced the contra...Continue Reading

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Citations

Jun 28, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Graham M Donovan
Oct 7, 2016·Science Translational Medicine·David C AdamsMelissa J Suter
Feb 21, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alvenia CairncrossPeter K McFawn
Nov 16, 2016·Respiratory Research·Morgan Le GuenChristophe Faisy
Apr 20, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Kimberley C W WangPeter B Noble
Jun 16, 2017·Physiology·Kenneth R LutchenChun Y Seow

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