PMID: 9174656Apr 1, 1997Paper

Does sympathetic activation blunt nitric oxide-mediated hyperemia in the human forearm?

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
K A EngelkeMichael J Joyner

Abstract

To determine if the vasodilating substance nitric oxide (NO) interferes with the ability of sympathetic nerves to regulate blood flow in humans, forearm blood flow (FBF) was measured during brachial artery infusions of acetylcholine (ACh) to evoke endothelial NO release, and during infusions of the NO donor nitroprusside (NTP) in five healthy volunteers. Sympathetic activity was increased by application of lower body suction and antagonized by brachial artery infusions of phentolamine. In the control condition, FBF was 2.4 +/- 0.4 ml/100 ml per min and rose by 16.9 +/- 3.6 ml/100 ml per min during ACh at 16 micrograms/min and by 17.0 +/- 4.3 ml/100 ml per min at 64 micrograms/min. With suction, FBF was 1.7 +/- 0.6 ml/100 ml per min (p < 0.05 versus control) and rose by 11.4 +/- 3.2 ml/100 ml per min during ACh at 16 micrograms/min (p < 0.05 versus control). After phentolamine, FBF was 3.8 +/- 0.5 ml/100 ml per min at baseline (p < 0.05 versus control) and the increases in flow with ACh at either 16 or 64 micrograms/min were identical to control. During the control NTP trial, FBF rose by 6.3 +/- 1.1 ml/100 ml per min with NTP at 2.5 micrograms/min and by 12.1 +/- 1.4 ml/100 ml per min at 10 micrograms/min. Suction blunted and ph...Continue Reading

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Citations

Mar 29, 2007·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Christopher L KaufmanDonald R Dengel
Feb 19, 2002·Journal of the American College of Cardiology·Michel L HijmeringTon J Rabelink
Oct 11, 2003·American Journal of Respiratory and Critical Care Medicine·Mary S M IpWah-Kit Lam
Jul 9, 2014·The British Journal of Oral & Maxillofacial Surgery·JiSi ZhengJingYang Zhao
Nov 27, 2007·Journal of the American College of Cardiology·Marco GuazziMaurizio D Guazzi
Dec 7, 2007·Journal of the International Society of Sports Nutrition·Richard J BloomerKelsey H Fisher-Wellman
May 18, 2016·Respiratory Research·Diego Orbegozo CortésJean-Louis Vincent
Feb 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Marco GuazziMaurizio D Guazzi
Aug 19, 2003·Journal of Applied Physiology·Jaya B RosenmeierMichael J Joyner
Jan 15, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Emma C HartNisha Charkoudian

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