Does the Addenbrooke's Cognitive Examination-revised add to the Mini-Mental State Examination in established Alzheimer disease? Results from a national dementia research register.

International Journal of Geriatric Psychiatry
Emma LawJohn M Starr

Abstract

To evaluate how much the Addenbrooke's Cognitive Examination-revised (ACE-R) improves the estimate of cognitive ability from the Mini-Mental State Examination (MMSE) in people with Alzheimer disease (AD). We examined itemized data in people with AD who were on the Scottish Dementia Research Interest Register drawn from eight centres across Scotland, covering 75% of the Scottish population. ACE-R items that comprise the MMSE and those that did not (non-MMSE items) were summed separately. We residualized MMSE total on non-MMSE total and vice versa to derive a measure of the variance unique to each. Five hundred and one (258 male, 243 female) participants, mean age 75.7 (range 52-94) years were on the register, of whom 329 (160 men, 169 women) had AD. Of those with AD, 309 had a mean MMSE of 20.5 and mean ACE-R of 57.5 measured with Pearson r = 0.92 between MMSE and ACE-R totals, and the regression equation ACE-R score = 3.0 × MMSE - 4.1. The unique non-MMSE items score correlated with ACE-R total r = 0.40 (16% of ACE-R variance). The ACE-R and MMSE total scores are highly correlated. In this clinical sample of people with established AD, for an MMSE score of 24, the predicted ACE-R score was 67.9 with 95% confidence intervals of ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 24, 2004·Dementia and Geriatric Cognitive Disorders·Sarah E Voss, Roger A Bullock
Sep 16, 2006·International Journal of Geriatric Psychiatry·Eneida MioshiJohn R Hodges
Aug 4, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Jane A LonieKlaus P Ebmeier

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Citations

Nov 15, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Tom C RussJohn M Starr
Aug 8, 2015·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Joanna AtkinsonBencie Woll
Sep 11, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Catherine A HumphreysColin Smith
Mar 23, 2019·Experimental Aging Research·Mario A Parra, Rini I Kaplan
Nov 2, 2013·Expert Review of Neurotherapeutics·Craig Gordon, Daniel J Martin
Apr 23, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G P KostyukI V Reverchuk
Dec 7, 2013·International Journal of Geriatric Psychiatry·Gemma AlcornJohn M Starr
Oct 11, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·T A Polyakova, O S Levin
Oct 14, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Qianqian WeiHuifang Shang
Aug 2, 2017·Journal of Alzheimer's Disease : JAD·Ratko RadakovicSharon Abrahams
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·John MaltbyElizabeta B Mukaetova-Ladinska
Aug 8, 2019·Dementia and Geriatric Cognitive Disorders·Ozge Karadag CamanYavuz Ayhan

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