Does the age-related change in CD44-defined T-cell subsets have functional significance for cytotoxic T lymphocyte generation?

Immunology Letters
E T BloomJ A Horvath

Abstract

CD44 or Pgp-1 is a transmembrane leukocyte adhesion-related glycoprotein which is often expressed in greater density on the membranes of memory T lymphocytes (CD44hi) compared to naive T cells (CD44lo). The proportion of Pgphi or CD44hi cells among T cells is increased with advancing age. We examined the relevance of this alteration for the age-related decrease in the generation of allospecific CTL activity. The findings confirm the age-related increase in the frequency of CD44hi cells in spleens of aged mice of several strains, but also show interstrain variability in the magnitude of the increase (bm1 > C57BL/6 > BALB/c). In contrast, we found that after allo-stimulation, the proportion of cells bearing the memory phenotype is decreased in cells from aged mice, particularly within the CD8+ T cell subset. To determine if these observations reflected an alteration in the frequency or responsiveness of naive T cells, enriched populations of spleen cells depleted of CD44hi cells were prepared from spleen cells of young and aged mice, and stimulated in mixed lymphocyte culture. Enrichment for cells expressing the naive phenotype did not restore the ability of T cells from aged mice to generate allospecific CTL. Together, these fin...Continue Reading

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L J Wysocki, V L Sato
Dec 1, 1978·Immunogenetics·H I KohnD C Shreffler

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Citations

Jul 16, 1999·Mechanisms of Ageing and Development·B Chakravarti, G N Abraham
Aug 30, 2003·Brain, Behavior, and Immunity·J A WoodsQ Lu
Feb 1, 1997·Journal of Gastroenterology and Hepatology·K A HeelJ C Hall
Jan 11, 2008·American Journal of Physiology. Cell Physiology·Yan ZhangWen-Hui Wang
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jayne S SutherlandRichard L Boyd
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja C RodenEugene D Kwon
Jun 4, 2018·Developmental and Comparative Immunology·Sita S WithersRobert B Rebhun

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