Does the Association of Diabetes With Stroke Risk Differ by Age, Race, and Sex? Results From the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Diabetes Care
Gargya MallaApril P Carson

Abstract

Given temporal changes in diabetes prevalence and stroke incidence, this study investigated age, race, and sex differences in the diabetes-stroke association in a contemporary prospective cohort, the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. We included 23,002 non-Hispanic black and white U.S. adults aged ≥45 years without prevalent stroke at baseline (2003-2007). Diabetes was defined as fasting glucose ≥126 mg/dL, random glucose ≥200 mg/dL, or use of glucose-lowering medication. Incident stroke events were expert adjudicated and available through September 2017. The prevalence of diabetes was 19.1% at baseline. During follow-up, 1,018 stroke events occurred. Among adults aged <65 years, comparing those with diabetes to those without diabetes, the risk of stroke was increased for white women (hazard ratio [HR] 3.72 [95% CI 2.10-6.57]), black women (HR 1.88 [95% CI 1.22-2.90]), and white men (HR 2.01 [95% CI 1.27-3.27]) but not black men (HR 1.27 [95% CI 0.77-2.10]) after multivariable adjustment. Among those aged ≥65 years, diabetes increased the risk of stroke for white women and black men, but not black women (HR 1.05 [95% CI 0.74-1.48]) or white men (HR 0.86 [95% CI 0.62-1.21]). In this contemp...Continue Reading

References

May 29, 1998·Circulation·P W WilsonW B Kannel
Jan 28, 2003·Diabetes Care·M WoodwardUNKNOWN Asia Pacific Cohort Studies Collaboration
Jul 2, 2005·Neuroepidemiology·Virginia J HowardGeorge Howard
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 10, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·David G WarnockUNKNOWN REGARDS Investigators
Mar 19, 2011·Annals of Neurology·Virginia J HowardGeorge Howard
Mar 3, 2012·Stroke; a Journal of Cerebral Circulation·Chirantan BanerjeeMitchell S V Elkind
Apr 27, 2013·Stroke; a Journal of Cerebral Circulation·Jane C KhouryBrett M Kissela
Sep 12, 2013·Cancer·Jay S Kaufman, Richard F MacLehose
Jul 17, 2014·JAMA : the Journal of the American Medical Association·Silvia KotonJosef Coresh
Sep 24, 2014·JAMA : the Journal of the American Medical Association·Linda S GeissEdward W Gregg
Nov 12, 2014·The American Journal of Tropical Medicine and Hygiene·Kaitlin A O'KeefeFrank J Sorvillo
Oct 22, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Wesley T O'NealElsayed Z Soliman
Apr 16, 2016·The American Journal of the Medical Sciences·Rong ChenWuwei Feng
Feb 6, 2017·Circulation·Carole DufouilSudha Seshadri
May 5, 2017·MMWR. Morbidity and Mortality Weekly Report·Timothy J CunninghamWayne H Giles
Nov 20, 2018·American Journal of Epidemiology·D Leann LongM Maria Glymour
Apr 16, 2019·JAMA : the Journal of the American Medical Association·Edward W GreggStephen R Benoit

❮ Previous
Next ❯

Citations

Oct 27, 2020·Stroke; a Journal of Cerebral Circulation·Deborah A LevineOlugbenga G Ogedegbe
Dec 11, 2020·Journal of Diabetes·Zachary Bloomgarden, Robert Chilton
Sep 17, 2021·Diabetes/metabolism Research and Reviews·Sian A BradleySonu M M Bhaskar

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.