Does the clinical course of depression determine improvement in symptoms and quality of life?

The Journal of Nervous and Mental Disease
Tally MosesMichelle Abrams

Abstract

Clinical course factors characterizing individuals' history with depression may be helpful in predicting treatment-related change in quality of life (QOL). Such factors have been studied in relation to symptomatic change with mixed results. This 9-week single-blind treatment trial using reboxetine (1 week placebo lead-in) evaluated the impact of age of onset, history of antidepressant treatment, duration of index episode, number of past episodes, and the presence of precipitating stress on depressed individuals' treatment response. We found that QOL did not normalize along with clinical remission in all areas. Using multivariate analysis, we found that age of onset, history with antidepressants, and the presence of identifiable precipitating stress were all significant predictors of QOL change (controlling for symptomatic change); some factors also predicted symptomatic improvement. Our results support the trend of distinguishing between treatment-related change in QOL and symptomatic change and suggest clinical course factors as promising predictors of QOL.

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Citations

Dec 6, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Rongrong TaoCarroll Hughes
Sep 22, 2019·Social Psychiatry and Psychiatric Epidemiology·Karin C P RemmerswaalAnton J L M van Balkom
Sep 20, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Eva GoppoldovaTomas Hajek

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