Does the cognitive architecture of simplex and multiplex ASD families differ?

Journal of Autism and Developmental Disorders
Anoek M OerlemansNanda N J Rommelse

Abstract

Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD.

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Citations

Nov 3, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Lien Van EylenIlse Noens
Nov 27, 2018·Autism Research : Official Journal of the International Society for Autism Research·Niamh PearsonFiona S McEwen
Jan 22, 2019·Autism Research : Official Journal of the International Society for Autism Research·Cheryl DissanayakeLauren P Lawson
Apr 30, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Megan MichelettiAmi Klin
May 19, 2019·Journal of Autism and Developmental Disorders·Daniel BerendsLauren P Lawson
Feb 23, 2017·Journal of Autism and Developmental Disorders·Lori-Ann R SacreyMayada Elsabbagh

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Amsterdam Neuropsychological Tasks ( ANT )

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