Does the constellation of risk factors with and without abdominal adiposity associate with different cardiovascular mortality risk?

International Journal of Obesity : Journal of the International Association for the Study of Obesity
W Gao, DECODE Study Group

Abstract

To evaluate whether the metabolic syndrome (MetS) defined by the International Diabetes Federation (IDF) criteria, which has abdominal adiposity as a mandatory element, predicts cardiovascular disease (CVD) mortality better than the cluster of other IDF-defined abnormalities not including abdominal adiposity. Data from nine European population-based studies, including 7782 men and 7739 women (aged 30-89 years), with a median follow-up of 8.55 years, were jointly analyzed. Hazard ratios for CVD mortality were calculated with Cox regression models. In total, 41% of the men and 38% of the women had the IDF MetS. Individuals with the IDF MetS were by definition more obese and had a higher prevalence of diabetes than non-obese subjects with > or = 2 IDF abnormalities; whereas non-obese men with > or = 3 factors had more atherogenic lipid profiles. Multivariate adjusted hazard ratio for CVD death in men and women with the IDF MetS was 2.44 (1.69-2.98) and 2.32 (1.27-4.23); in non-obese men with 2 and > or = 3 factors the hazard ratio was 1.60 (1.12-2.30) and 2.44 (1.62-3.66), respectively, and in non-obese women with 2 factors the hazard ratio was 2.41 (1.09-5.33). The cluster of the CVD risk factors predicted CVD mortality regardles...Continue Reading

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Citations

Mar 29, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Isao Saito
Mar 4, 2014·Endocrinology and Metabolism Clinics of North America·Susan L Samson, Alan J Garber
Apr 18, 2015·BMC Endocrine Disorders·Victoria Mendoza-ZubietaAldo Ferreira-Hermosillo
Nov 27, 2009·Postgraduate Medicine·Xavier Pi-Sunyer
Sep 29, 2019·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Saibin WangQian Ye
Mar 19, 2020·International Journal of Molecular Sciences·Grazia RutiglianoGrazia Chiellini
Mar 29, 2011·The Tohoku Journal of Experimental Medicine·Mariko InoueEiji Yano
Oct 31, 2020·Cardiovascular Therapeutics·Małgorzata MaciorowskaGrzegorz Gielerak
Apr 29, 2021·Journal of Food Science·Andrea R Gómez-FernándezDaniel A Jacobo-Velázquez
Oct 10, 2021·Endocrine·Nikoletta MiliTheodora Psaltopoulou

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