Does the duration of cardiopulmonary bypass or aortic cross-clamp, in the absence of blood and/or blood product administration, influence the IL-6 response to cardiac surgery?

Anesthesia and Analgesia
C W WhittenJ M Lipton

Abstract

Cardiopulmonary bypass (CPB) induces a systemic inflammatory response characterized by release of proinflammatory cytokines, including interleukin 6 (IL-6). Recent reports suggest that plasma IL-6 is increased after CPB. Previous studies evaluating the influence of duration of CPB and/or aortic cross-clamp time on the release of IL-6 are conflicting. Infusion of blood and blood products during these studies may have influenced plasma concentrations of proinflammatory cytokines by inducing host cell (monocyte) activation and IL-6 release. The purpose of our investigation was to determine, in an environment free from blood and/or blood product administration, the influence of duration of CPB and/or aortic cross-clamp on the magnitude of the IL-6 response in patients undergoing cardiac surgery. We prospectively evaluated plasma IL-6 levels preinduction (T0) and at sternal closure in 16 patients undergoing CPB (coronary artery bypass grafting, n = 9; valvular cardiac surgery, n = 7) to determine whether there is a correlation between the absolute increase in IL-6 and the duration of CPB or aortic cross-clamp time. None of the patients received blood and/or blood products during the study to control for the introduction of additiona...Continue Reading

References

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Citations

Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Johannes M AlbesThorsten Wahlers
Aug 18, 2000·Anaesthesia·S A Helmy, R J Al-Attiyah
Apr 25, 2012·Annals of Pediatric Cardiology·Ajay K GuptaAmit Varma
Oct 25, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Stefano SalisErminio Sisillo
Aug 10, 2005·Biochemical and Biophysical Research Communications·Mladen PavlovicSabina Gallati
Nov 9, 2004·Journal of Diabetes and Its Complications·Hillary A TuttlePaul F McDonagh
Jan 6, 2000·Journal of Cardiothoracic and Vascular Anesthesia·A MaslowR G Johnson
Jul 14, 2016·Journal of Cardiothoracic Surgery·Blake ShultzRobert Hooker
Dec 1, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jochen RennerOle Broch
Feb 12, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K KawahitoT Ino
Jun 13, 2002·Anaesthesia·R M HeamesD A Hett
Dec 25, 2013·Lymphatic Research and Biology·Artur SchanderLisa M Hodge
Aug 25, 1999·Anaesthesia·S A HelmyM El-Nawaway

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