Abstract
The hematopoietic cell transplantation specific comorbidity index (HCT-CI) has been recently proposed to predict the probability of nonrelapse mortality (NRM) and overall survival (OS) in allogeneic HCT recipients while taking into account any pretransplant comorbidity. We tested the validity of the HCT-CI in a cohort of 373 adult HCT recipients (184 matched-related donor and 189 unrelated umbilical cord blood) who received a myeloablative (N = 150) or nonmyeloablative (N = 223) conditioning regimen. HCT-CI scores of 0, 1, 2, and > or =3 were present in 58 (16%), 56 (15%), 64 (17%), and 195 (52%) patients, respectively. Pulmonary conditions were the most common comorbidity. Cumulative incidence of NRM at 2 years was 10%, 20%, 24%, and 28% for HCT-CI scores of 0, 1, 2, and > or =3, respectively (P = .01). The corresponding probability of OS at 2 years was 72%, 67%, 51%, and 48%, respectively (P < .01). On multivariate analyses adjusted for recipient age, disease risk, donor source, and conditioning regimen intensity, the relative risks for NRM for HCT-CI scores of 1, 2, and > or =3 (compared to a score of 0) were 2.0 (95% confidence intervals, 0.8-5.3), 2.6 (1.0-6.7), and 3.2 (1.4-7.4), respectively. The risks for overall mortal...Continue Reading
References
Apr 30, 1997·Statistics in Medicine·D Y Lin
May 9, 2001·Blood·V RochaE Gluckman
May 10, 2003·Blood·Juliet N BarkerJohn E Wagner
Dec 31, 2005·Blood·Navneet S MajhailLinda J Burns
Aug 10, 2006·Current Opinion in Immunology·Navneet S MajhailJohn E Wagner
Jun 16, 2007·Blood·Claudio G BrunsteinJohn E Wagner
Jul 10, 2007·American Journal of Hematology·Catherine M FlynnDaniel Weisdorf
Aug 29, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohamed L SorrorRainer Storb
Sep 18, 2007·Blood·Mohamed L SorrorRainer Storb
Oct 6, 2007·Blood·Mohamed L SorrorRainer Storb
Nov 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marco MielcarekRainer Storb
Citations
Jun 26, 2010·International Journal of Hematology·Mats Remberger, Jonas Mattsson
Apr 16, 2013·International Journal of Hematology·S Fadilah Abdul Wahid
Jul 9, 2013·Leukemia Research·Shahrukh HashmiMichael W Becker
Aug 18, 2009·Bone Marrow Transplantation·K KataokaM Kurokawa
Oct 6, 2009·Bone Marrow Transplantation·T E DeForC T Le
Nov 9, 2010·Bone Marrow Transplantation·S El KourashyJ A Russell
Apr 13, 2010·Bone Marrow Transplantation·J R Long-BoyleP A Jacobson
May 25, 2011·Leukemia·T LodewyckJ J Cornelissen
Jan 15, 2010·Current Opinion in Hematology·Brian L McClune, Daniel J Weisdorf
Jan 18, 2011·Hematology·Mohamed L Sorror
Dec 17, 2009·Haematologica·Theis H TerweyRenate Arnold
Apr 15, 2014·ISRN Hematology·Jens M ChemnitzChristof Scheid
Aug 12, 2014·Bone Marrow Transplantation·V AllareddyA T Rotta
May 5, 2009·Seminars in Oncology Nursing·Nonniekaye Shelburne, Margaret Bevans
May 23, 2014·American Journal of Hematology·Wataru YamamotoHeiwa Kanamori
Jul 19, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Aya NakayaShinichiro Okamoto
May 7, 2015·British Journal of Haematology·Mahmoud ElSawyMohamed L Sorror
Aug 12, 2015·Annals of Hematology·G ChakupurakalC Scheid
Jun 2, 2015·Bone Marrow Transplantation·B K HamiltonN S Majhail
Sep 14, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael J BurkeMichael R Verneris
Feb 11, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Barbara DeschlerJürgen Finke
Dec 3, 2014·Clinical Lymphoma, Myeloma & Leukemia·Fotios V MichelisDennis Dong Hwan Kim
May 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamed L SorrorRainer F Storb
Oct 22, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William A WoodSergio A Giralt
Nov 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pere BarbaJorge Sierra
Jan 13, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Erica D WarlickDaniel Weisdorf
Jun 29, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nicole BirningerJohannes Schetelig
Jun 29, 2012·Blood·Roberto RaimondiAlberto Bosi
Jan 14, 2011·Blood·Angela R SmithStella M Davies
Jun 9, 2016·Bone Marrow Transplantation·M Elsawy, M L Sorror
Dec 7, 2010·Bone Marrow Transplantation·P PatelD Rondelli
Nov 22, 2011·Bone Marrow Transplantation·Y MoriK Akashi
Jun 26, 2010·Bone Marrow Transplantation·M L SorrorR Storb
Oct 12, 2018·Drugs & Aging·Zeina Al-MansourJan Cerny
Jul 12, 2011·Bone Marrow Transplantation·S W BokhariN H Russell
Mar 9, 2011·Pediatric Blood & Cancer·William WoodThomas Shea
Aug 22, 2018·Bone Marrow Transplantation·Wallace BourgeoisPrakash Satwani
Jan 25, 2019·Blood Advances·Nelli BejanyanDaniel J Weisdorf
Aug 13, 2020·Bone Marrow Transplantation·Christopher LemieuxSurbhi Sidana
Nov 28, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meng LvXiao-Jun Huang
Jan 19, 2019·Leukemia Research·Christopher LemieuxSilvy Lachance
Jun 17, 2020·Hematology, Transfusion and Cell Therapy·Eucario Leon-RodriguezIsabel Katherine Lastra-German
Aug 12, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rashmika PotdarRoni Shouval