Does the Knowledge of the Local Thickness of Human Ascending Thoracic Aneurysm Walls Improve Their Mechanical Analysis?

Frontiers in Bioengineering and Biotechnology
C CavinatoPierre Badel

Abstract

Ascending thoracic aortic aneurysm (ATAA) ruptures are life threatening phenomena which occur in local weaker regions of the diseased aortic wall. As ATAAs are evolving pathologies, their growth represents a significant local remodeling and degradation of the microstructural architecture and thus their mechanical properties. To address the need for deeper study of ATAAs and their failure, it is required to analyze the mechanical behavior at the sub-millimeter scale by making use of accurate geometrical and kinematical measurements during their deformation. For this purpose, we propose a novel methodology that combined an accurate tool for thickness distribution measurement of the arterial wall, digital image correlation to assess local strain fields and bulge inflation to characterize the physiological and failure response of flat unruptured human ATAA specimens. The analysis of the heterogeneity of the local thickness and local physiological stress and strain was carried out for each investigated subject. At the subject level, our results state the presence of a non-consistent relationship between the local wall thickness and the local physiological strain field and high heterogeneity of the variables. At the inter-subject lev...Continue Reading

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Citations

Sep 29, 2020·Frontiers in Bioengineering and Biotechnology·Baptiste PierratAisling Ní Annaidh
Aug 15, 2020·Journal of Biomechanical Engineering·Dhananjay Radhakrishnan SubramaniamIris Gutmark-Little
Aug 23, 2020·Journal of Biomechanics·Thibaud CochereauMaxime Terrien

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Methods Mentioned

BETA
dissection

Software Mentioned

Matlab®
Aramis®
LabVIEW

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